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Measurement of H-1-H-1 residual dipolar coupling constants for structural studies of medium size molecules
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Jin, Lan, Pham, Tran N. and Uhrin, Dusan (2007) Measurement of H-1-H-1 residual dipolar coupling constants for structural studies of medium size molecules. ChemPhysChem, Vol.8 (No.8). pp. 1228-1235. doi:10.1002/cphc.200700071 ISSN 1439-4235.
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Official URL: http://dx.doi.org/10.1002/cphc.200700071
Abstract
Residual dipolar coupling constants (RDCs) are being increasingly applied to elucidate the configuration and conformation of small organic molecules, peptides and oligosaccharides. In this paper we describe a set of robust 1D NMR methods for accurate and precise measurement of proton-proton RDCs of small and medium size molecules. The performance of these techniques is not impeded by the presence of overlapping and broad H-1 multiplets that are typically observed for such molecules in weakly Introduction aligned media. The use of these techniques provides access to a large pool of proton-proton RDCs opening new avenues for the solution structure elucidation of medium size molecules by NMR. The techniques are illustrated on the determination of the alignment tensor of the reducing monosaccharide ring of cellobiose and the determination of the relative configuration of sodium cholate.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry Q Science > QC Physics |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||
Journal or Publication Title: | ChemPhysChem | ||||
Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||
ISSN: | 1439-4235 | ||||
Official Date: | 4 June 2007 | ||||
Dates: |
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Volume: | Vol.8 | ||||
Number: | No.8 | ||||
Number of Pages: | 8 | ||||
Page Range: | pp. 1228-1235 | ||||
DOI: | 10.1002/cphc.200700071 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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