Ihnat, M. A., Thorpe, J. E. and Ceriello, A. (2007) Hypothesis: the 'metabolic memory', the new challenge of diabetes. Diabetic Medicine, Vol.24 (No.6). pp. 582-586. ISSN 0742-3071

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Abstract

Large randomized studies have established that early intensive glycaemic control reduces the risk of diabetic complications, both micro- and macrovascular. However, epidemiological and prospective data support a long-term influence of early metabolic control on clinical outcomes. This phenomenon has recently been defined as 'metabolic memory.' Potential mechanisms for propagating this 'memory' are the non-enzymatic glycation of cellular proteins and lipids, and an excess of cellular reactive oxygen and nitrogen species, in particular originated at the level of glycated-mitochondrial proteins, perhaps acting in concert with one another to maintain stress signalling. Furthermore, the emergence of this 'metabolic memory' suggests the need for very early aggressive treatment aiming to 'normalize' glycaemic control and the addition of agents which reduce cellular reactive species and glycation in order to minimize long-term diabetic complications.

Item Type:	Journal Item
Subjects:	R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI)
Journal or Publication Title:	Diabetic Medicine
Publisher:	Blackwell
ISSN:	0742-3071
Date:	June 2007
Volume:	Vol.24
Number:	No.6
Number of Pages:	5
Page Range:	pp. 582-586
Identification Number:	10.1111/j.1464-5491.2007.02138.x
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/31890

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