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MbtH-like protein-mediated cross-talk between non-ribosomal peptide antibiotic and siderophore biosynthetic pathways in Streptomyces coelicolor M145
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Lautru, Sylvie, Oves-Costales, Daniel, Pernodet, Jean-Luc and Challis, Gregory L. (2007) MbtH-like protein-mediated cross-talk between non-ribosomal peptide antibiotic and siderophore biosynthetic pathways in Streptomyces coelicolor M145. Microbiology, Vol.153 (No.5). pp. 1405-1412. doi:10.1099/mic.0.2006/003145-0 ISSN 1350-0872.
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Official URL: http://dx.doi.org/10.1099/mic.0.2006/003145-0
Abstract
MbtH-like proteins are a family of small proteins encoded by genes found in many, but not all, non-ribosomal peptide synthetase-encoding gene clusters that direct the biosynthesis of peptide antibiotics and siderophores. Studies published to date have not elucidated the function of MbtH-like proteins, nor have they clarified whether they are required for metabolite biosynthesis. Here it is shown that only one of two genes (cdaX or cchK) encoding MbtH-like proteins in Streptomyces coelicolor is required for biosynthesis of the peptide siderophore coelichelin and the calcium-dependent peptide antibiotic (CDA). The cdaX and cchK genes can functionally complement each other in trans, suggesting that CdaX and CchK can cross-talk with the coelichelin and CDA biosynthetic pathways, respectively. Transcriptional analyses of wild-type S. coelicolor and a double cchK/cdaX replacement mutant indicate that CchK and CdaX may not be involved in transcriptional regulation of coelichelin and CDA biosynthetic gene clusters.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QR Microbiology | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
| Journal or Publication Title: | Microbiology | ||||
| Publisher: | Society for General Microbiology | ||||
| ISSN: | 1350-0872 | ||||
| Official Date: | May 2007 | ||||
| Dates: |
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| Volume: | Vol.153 | ||||
| Number: | No.5 | ||||
| Number of Pages: | 8 | ||||
| Page Range: | pp. 1405-1412 | ||||
| DOI: | 10.1099/mic.0.2006/003145-0 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
Data sourced from Thomson Reuters' Web of Knowledge
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