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Mathematical model of the antibody response to hepatitis B vaccines: implications for reduced schedules

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Wilson, Jamie N., Nokes, D. James, Medley, Graham and Shouval, Daniel. (2007) Mathematical model of the antibody response to hepatitis B vaccines: implications for reduced schedules. Vaccine, Vol.25 (No.18). pp. 3705-3712. ISSN 0264-410X

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Abstract

One of the cardinal features of the immune response is immune memory: the size of the secondary antibody response to vaccination reflects the amount of immune memory that has been generated in an individual by the priming dose. We construct a mathematical model of the generation of immune memory and antibody in response to hepatitis B vaccines. The model predictions are compared to post-vaccination antibody titres from eight adult vaccine trials. The model demonstrates significant differences between different vaccines in both the time taken to generate immune memory and the amount of memory generated. The model provides theoretical support for the hypothesis that a single vaccine dose can generate protective immune memory. (C) 2007 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine
Divisions: Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Journal or Publication Title: Vaccine
Publisher: Elsevier Ltd.
ISSN: 0264-410X
Official Date: 4 May 2007
Volume: Vol.25
Number: No.18
Number of Pages: 8
Page Range: pp. 3705-3712
Identification Number: 10.1016/j.vaccine.2007.01.012
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
URI: http://wrap.warwick.ac.uk/id/eprint/31936

Data sourced from Thomson Reuters' Web of Knowledge

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