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Effects of acute antipsychotic treatment on brain activation in first episode psychosis: an fMRI study
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Fusar-Poli, Paolo, Broome, Matthew R., Matthiasson, P., Williams, S. C. R., Brammer, M. and McGuire, Philip. (2007) Effects of acute antipsychotic treatment on brain activation in first episode psychosis: an fMRI study. European Neuropsychopharmacology, Vol.17 (No.6-7). pp. 492-500. ISSN 0924-977X
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Official URL: http://dx.doi.org/10.1016/j.euroneuro.2007.01.003
Abstract
This study aimed to assess the neurophysiotogical effects of acute atypical antipsychotic treatment on cognitive functioning in subjects presenting with a first episode of psychosis. We used functional MRI to examine the modulatory effects of acute psychopharmacological intervention on brain activation during four different cognitive tasks: overt verbal fluency, random movement generation, n-back and a spatial object memory task. Treatment with atypical antipsychotics was associated with alterations in regional activation during each task and also when task demands were manipulated within paradigms. The initial treatment of psychosis with atypical antipsychotics thus appears to be associated with modifications of the neurofunctional correlates of executive and mnemonic functions. These effects need to be considered when interpreting group differences in activation between medicated patients and controls. (C) 2007 Elsevier B.V. and ECNP. All rights reserved.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Medicine > Warwick Medical School |
| Journal or Publication Title: | European Neuropsychopharmacology |
| Publisher: | Elsevier BV |
| ISSN: | 0924-977X |
| Date: | May 2007 |
| Volume: | Vol.17 |
| Number: | No.6-7 |
| Number of Pages: | 9 |
| Page Range: | pp. 492-500 |
| Identification Number: | 10.1016/j.euroneuro.2007.01.003 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/31994 |
Data sourced from Thomson Reuters' Web of Knowledge
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