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Mutant p53 facilitates pro-angiogenic, hyperproliferative phenotype in response to chronic relative hypoxia
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Kamat, Chandrashekhar D., Green, Dixy E., Warnke, Linda, Thorpe, Jessica E., Ceriello, Antonio and Ihnat, Michael A. (2007) Mutant p53 facilitates pro-angiogenic, hyperproliferative phenotype in response to chronic relative hypoxia. Cancer Letters, Vol.249 (No.2). pp. 209-219. doi:10.1016/j.canlet.2006.08.017
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Official URL: http://dx.doi.org/10.1016/j.canlet.2006.08.017
Abstract
There is much controversy in the literature regarding the role of p53 status response on hypoxia inducible factor (HIF) signaling in response to chronic relative hypoxia (CRH). The goal of this paper was to methodically examine this response in isogenically matched tumor cells. We report that p53-mutant (MUT) cells, versus p53-wild-type (WT) cells, showed decreased apoptosis, increased cell proliferation with higher basal HIF-1 alpha levels in response to CRH. In addition, we found increased HIF-mediated transactivation and increased VEGF release with decreased HIF-1 alpha/p53 and HIF-1 alpha/ MDM-2 partnering in p53-MUT versus p53-WT cells in response to CRH. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||
| Divisions: | Faculty of Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | Cancer Letters | ||||
| Publisher: | Elsevier Ireland Ltd. | ||||
| ISSN: | 0304-3835 | ||||
| Official Date: | 8 May 2007 | ||||
| Dates: |
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| Volume: | Vol.249 | ||||
| Number: | No.2 | ||||
| Number of Pages: | 11 | ||||
| Page Range: | pp. 209-219 | ||||
| DOI: | 10.1016/j.canlet.2006.08.017 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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