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Formation of giant amphiphiles by post-functionalization of hydrophilic protein-polymer conjugates
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Le Droumaguet, Benjamin, Mantovani, Giuseppe, Haddleton, David M. and Velonia, Kelly (2007) Formation of giant amphiphiles by post-functionalization of hydrophilic protein-polymer conjugates. Journal of Materials Chemistry, Volume 17 (Number 19). pp. 1916-1922. doi:10.1039/b618079e ISSN 0959-9428.
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Official URL: http://dx.doi.org/10.1039/b618079e
Abstract
A novel, generic method for the synthesis of families of tri-block protein-polymer giant amphiphiles was designed and developed. We have synthesized a hydrophilic alpha-maleimido poly-1-alkyne with M-n = 9.5 kDa (H-1-NMR) and narrow PDi (1.15 as measured by SEC) via ATRP (Atom Transfer Radical Polymerization). This polymer was successfully coupled to BSA to afford a hydrophilic multifunctional bioconjugate which was isolated using protein purification techniques and fully characterized. Following the post-functionalization approach, we introduced hydrophobicity to the resulting hydrophilic biohybrid by a straightforward, high yield "click'"-chemistry cycloaddition step. The resulting tri-block protein-polymer amphiphiles were isolated and showed interesting aggregation patterns (TEM, confocal microscopy).
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry T Technology > TA Engineering (General). Civil engineering (General) |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Journal or Publication Title: | Journal of Materials Chemistry | ||||
Publisher: | Royal Society of Chemistry | ||||
ISSN: | 0959-9428 | ||||
Official Date: | 2007 | ||||
Dates: |
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Volume: | Volume 17 | ||||
Number: | Number 19 | ||||
Number of Pages: | 7 | ||||
Page Range: | pp. 1916-1922 | ||||
DOI: | 10.1039/b618079e | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published |
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