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Cajal bodies and the nucleolus are required for a plant virus systemic infection
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Kim, Sang Hyon, Ryabov, Eugene V., Kalinina, Natalia O., Rakitina, Daria V., Gillespie, Trudi, MacFarlane, Stuart, Haupt, Sophie, Brown, John W. S. and Taliansky, Michael. (2007) Cajal bodies and the nucleolus are required for a plant virus systemic infection. EMBO Journal, Vol.26 (No.8). pp. 2169-2179. ISSN 0261-4189
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Official URL: http://dx.doi.org/10.1038/sj.emboj.7601674
Abstract
The nucleolus and Cajal bodies (CBs) are prominent interacting subnuclear domains involved in a number of crucial aspects of cell function. Certain viruses interact with these compartments but the functions of such interactions are largely uncharacterized. Here, we show that the ability of the groundnut rosette virus open reading frame (ORF) 3 protein to move viral RNA long distances through the phloem strictly depends on its interaction with CBs and the nucleolus. The ORF3 protein targets and reorganizes CBs into multiple CB-like structures and then enters the nucleolus by causing fusion of these structures with the nucleolus. The nucleolar localization of the ORF3 protein is essential for subsequent formation of viral ribonucleoprotein (RNP) particles capable of virus long-distance movement and systemic infection. We provide a model whereby the ORF3 protein utilizes trafficking pathways involving CBs to enter the nucleolus and, along with fibrillarin, exit the nucleus to form viral 'transport-competent' RNP particles in the cytoplasm.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Science > Life Sciences (2010- ) > Warwick HRI (2004-2010) |
| Journal or Publication Title: | EMBO Journal |
| Publisher: | Nature Publishing Group |
| ISSN: | 0261-4189 |
| Date: | 18 April 2007 |
| Volume: | Vol.26 |
| Number: | No.8 |
| Number of Pages: | 11 |
| Page Range: | pp. 2169-2179 |
| Identification Number: | 10.1038/sj.emboj.7601674 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/32080 |
Data sourced from Thomson Reuters' Web of Knowledge
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