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Hypofractionated accelerated radiotherapy with concurrent chemotherapy for locally advanced squamous cell carcinoma of the head and neck
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Sanghera, Paul, McConkey, Christopher C., Ho, Kean-Fatt, Glaholm, John and Hartley, Andrew. (2007) Hypofractionated accelerated radiotherapy with concurrent chemotherapy for locally advanced squamous cell carcinoma of the head and neck. International Journal of Radiation: Oncology - Biology - Physics, Vol.67 (No.5). pp. 1342-1351. ISSN 0360-3016
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Official URL: http://dx.doi.org/10.1016/j.ijrobp.2006.11.015
Abstract
Purpose: To investigate the tumor control rates in locally advanced head-and-neck cancer using accelerated hypofractionated radiotherapy with chemotherapy. Methods and Materials: The data from patients with squamous cell cancer of the larynx, oropharynx, oral cavity, and hypopharynx (In national Union Against Cancer Stage II-IV), who received accelerated hypofractionated radiotherapy with chemotherapy between January 1, 1998, and April 1, 2005, were retrospectively analyzed. Two different chemotherapy schedules were used, carboplatin and methotrexate, both single agents administered on an outpatient basis. The endpoints were overall survival, local control, and disease-free survival. Results: A total of 81 patients were analyzed. The 2-year overall survival rate was 71.6% (95% confidence interval [CI], 61.5-81.8%). The 2-year disease-free survival rate was 68.6% (95% CI, 58.4-78.8%). The 2-year local control rate was 75.4% (95% CI, 65.6-85.1%). When excluding patients with Stage 11 oral cavity, larynx, and hypopharynx tumors, 68 patients remained. For these patients, the 2-year overall survival, local control, and disease-free survival rate was 67.6% (95% CI, 56.0-79.2%), 72.0% (95% CI, 61.0-83.0%), and 64.1% (95% CI, 52.6-75.7%), respectively. Conclusion: Accelerated hypofractionated radiotherapy and synchronous chemotherapy can achieve high tumor control rates while being :resource sparing and should be the subject of prospective evaluation. (c) 2007 Elsevier Inc.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine |
| Divisions: | Faculty of Medicine > Warwick Medical School |
| Journal or Publication Title: | International Journal of Radiation: Oncology - Biology - Physics |
| Publisher: | Elsevier Science Inc. |
| ISSN: | 0360-3016 |
| Date: | 1 April 2007 |
| Volume: | Vol.67 |
| Number: | No.5 |
| Number of Pages: | 10 |
| Page Range: | pp. 1342-1351 |
| Identification Number: | 10.1016/j.ijrobp.2006.11.015 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/32108 |
Data sourced from Thomson Reuters' Web of Knowledge
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