Modelling the control of cell proliferation by an anti-cancer agent
Ali, Reza, Evans, N. D., Campbell, Lee, Errington, Rachel J., Godfrey, Keith R., Smith, Paul J. (Paul James), 1953- and Chappell, M. J. (Michael J.) (2007) Modelling the control of cell proliferation by an anti-cancer agent. Measurement & Control, Vol.40 (No.1). pp. 12-15. ISSN 0020-2940
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A mathematical model has been developed which describes human cell growth in the presence of topotecan (TPT), an anti-cancer agent. Previously, a model was developed for the pharmacokinetics (PK) of TPT, this provided a description of the activity of TPT and the subsequent delivery of the active form to the nuclear DNA target. This model is described briefly in this paper. The development of a new pharmacodynamic (PD) model for cell growth, based on a well-known cell cycle model is then discussed. The linking of the PK model to the PD model is considered with respect to the modulation of cell growth. Our PK-PD model has good agreement with in vitro experimental data. In a clinical context, it is intended that the model will be used for discovering routes for drug resistance and eventually as a tool for improving drug treatments for patients.
|Item Type:||Submitted Journal Article|
|Subjects:||R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)|
|Divisions:||Faculty of Science > Engineering|
|Library of Congress Subject Headings (LCSH):||Cells -- Growth -- Mathematical models, Antineoplastic agents -- Mathematical models, Drugs -- Physiological effect -- Mathematical models|
|Journal or Publication Title:||Measurement & Control|
|Publisher:||Sage Publications Ltd.|
|Official Date:||February 2007|
|Number of Pages:||4|
|Page Range:||pp. 12-15|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Research Councils UK (RCUK)|
|Grant number:||88/E19305 (BBSRC)|
 Bailly, C., “Topoisomerase I poisons and suppressors as anticancer drugs” Current Medicinal Chemistry, 7, pp. 39-58, 2000.
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