Modelling the control of cell proliferation by an anti-cancer agent
Ali, Reza, Evans, N. D., Campbell, Lee, Errington, Rachel J., Godfrey, Keith R., Smith, Paul J. and Chappell, M. J. (2007) Modelling the control of cell proliferation by an anti-cancer agent. Measurement & Control, Vol.40 (No.1). pp. 12-15. ISSN 0020-2940
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A mathematical model has been developed which describes human cell growth in the presence of topotecan (TPT), an anti-cancer agent. Previously, a model was developed for the pharmacokinetics (PK) of TPT, this provided a description of the activity of TPT and the subsequent delivery of the active form to the nuclear DNA target. This model is described briefly in this paper. The development of a new pharmacodynamic (PD) model for cell growth, based on a well-known cell cycle model is then discussed. The linking of the PK model to the PD model is considered with respect to the modulation of cell growth. Our PK-PD model has good agreement with in vitro experimental data. In a clinical context, it is intended that the model will be used for discovering routes for drug resistance and eventually as a tool for improving drug treatments for patients.
|Item Type:||Submitted Journal Article|
|Subjects:||R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)|
|Divisions:||Faculty of Science > Engineering|
|Library of Congress Subject Headings (LCSH):||Cells -- Growth -- Mathematical models, Antineoplastic agents -- Mathematical models, Drugs -- Physiological effect -- Mathematical models|
|Journal or Publication Title:||Measurement & Control|
|Publisher:||Sage Publications Ltd.|
|Official Date:||February 2007|
|Number of Pages:||4|
|Page Range:||pp. 12-15|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Research Councils UK (RCUK)|
|Grant number:||88/E19305 (BBSRC)|
 Bailly, C., “Topoisomerase I poisons and suppressors as anticancer drugs” Current Medicinal Chemistry, 7, pp. 39-58, 2000.
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