Ceriello, Antonio, Kumar, Sudhesh, Piconi, Ludovica, Esposito, Katerine and Giugliano, Dario. (2007) Simultaneous control of hyperglycemia and oxidative stress normalizes endothelial function in type 1 diabetes. Diabetes Care, Vol.30 (No.3). pp. 649-654. ISSN 0149-5992

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Abstract

OBJECTIVE - Previous studies have shown that in type I diabetes endothelial dysfunction persists even when glycemia is normalized. Moreover, oxidative stress has recently been demonstrated to be the mediator of hyperglycemia-induced endothelial dysfunction.

RESEARCH DESIGN AND METHODS - Thirty-six type 1 diabetic patients and 12 control subjects were enrolled. The diabetic patients were divided into three groups. The first group was treated for 24 h with insulin, achieving a near-normalization of glycemia. After 12 h of this treatment, vitamin C was added for the remaining 12 h. The second group was treated for 24 h with vitamin C. After 12 h of this treatment, insulin was started, with achievement of near-normalization of glycemia for the remaining 12 h. The third group was treated for 24 h with both vitamin C and insulin, achieving near-normalization of glycemia.

RESULTS - Neither normalization of glycemia nor vitamin C treatment alone was able to normalize endothelial dysfunction or oxidative stress. However, a combination of insulin and vitamin C normalized enclothelial dysfunction and decreased oxidative stress to normal levels.

CONCLUSIONS - This study suggests that long-lasting hyperglycemia in type I diabetic patients induces permanent alterations in endothelial cells, which may contribute to endothelial dysfunction by increased oxidative stress even when hyperglycemia is normalized.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Diabetes Care
Publisher:	American Diabetes Association
ISSN:	0149-5992
Official Date:	March 2007
Volume:	Vol.30
Number:	No.3
Number of Pages:	6
Page Range:	pp. 649-654
Identification Number:	10.2337/dc06-2048
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/32242

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