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Simultaneous control of hyperglycemia and oxidative stress normalizes endothelial function in type 1 diabetes
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Ceriello, Antonio, Kumar, Sudhesh, Piconi, Ludovica, Esposito, Katerine and Giugliano, Dario (2007) Simultaneous control of hyperglycemia and oxidative stress normalizes endothelial function in type 1 diabetes. Diabetes Care, Vol.30 (No.3). pp. 649-654. doi:10.2337/dc06-2048
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Official URL: http://dx.doi.org/10.2337/dc06-2048
Abstract
OBJECTIVE - Previous studies have shown that in type I diabetes endothelial dysfunction persists even when glycemia is normalized. Moreover, oxidative stress has recently been demonstrated to be the mediator of hyperglycemia-induced endothelial dysfunction.
RESEARCH DESIGN AND METHODS - Thirty-six type 1 diabetic patients and 12 control subjects were enrolled. The diabetic patients were divided into three groups. The first group was treated for 24 h with insulin, achieving a near-normalization of glycemia. After 12 h of this treatment, vitamin C was added for the remaining 12 h. The second group was treated for 24 h with vitamin C. After 12 h of this treatment, insulin was started, with achievement of near-normalization of glycemia for the remaining 12 h. The third group was treated for 24 h with both vitamin C and insulin, achieving near-normalization of glycemia.
RESULTS - Neither normalization of glycemia nor vitamin C treatment alone was able to normalize endothelial dysfunction or oxidative stress. However, a combination of insulin and vitamin C normalized enclothelial dysfunction and decreased oxidative stress to normal levels.
CONCLUSIONS - This study suggests that long-lasting hyperglycemia in type I diabetic patients induces permanent alterations in endothelial cells, which may contribute to endothelial dysfunction by increased oxidative stress even when hyperglycemia is normalized.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine | ||||
| Divisions: | Faculty of Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | Diabetes Care | ||||
| Publisher: | American Diabetes Association | ||||
| ISSN: | 0149-5992 | ||||
| Official Date: | March 2007 | ||||
| Dates: |
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| Volume: | Vol.30 | ||||
| Number: | No.3 | ||||
| Number of Pages: | 6 | ||||
| Page Range: | pp. 649-654 | ||||
| DOI: | 10.2337/dc06-2048 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
Data sourced from Thomson Reuters' Web of Knowledge
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