Simultaneous control of hyperglycemia and oxidative stress normalizes endothelial function in type 1 diabetes
Ceriello, Antonio, Kumar, Sudhesh, Piconi, Ludovica, Esposito, Katerine and Giugliano, Dario. (2007) Simultaneous control of hyperglycemia and oxidative stress normalizes endothelial function in type 1 diabetes. Diabetes Care, Vol.30 (No.3). pp. 649-654. ISSN 0149-5992Full text not available from this repository.
Official URL: http://dx.doi.org/10.2337/dc06-2048
OBJECTIVE - Previous studies have shown that in type I diabetes endothelial dysfunction persists even when glycemia is normalized. Moreover, oxidative stress has recently been demonstrated to be the mediator of hyperglycemia-induced endothelial dysfunction. RESEARCH DESIGN AND METHODS - Thirty-six type 1 diabetic patients and 12 control subjects were enrolled. The diabetic patients were divided into three groups. The first group was treated for 24 h with insulin, achieving a near-normalization of glycemia. After 12 h of this treatment, vitamin C was added for the remaining 12 h. The second group was treated for 24 h with vitamin C. After 12 h of this treatment, insulin was started, with achievement of near-normalization of glycemia for the remaining 12 h. The third group was treated for 24 h with both vitamin C and insulin, achieving near-normalization of glycemia. RESULTS - Neither normalization of glycemia nor vitamin C treatment alone was able to normalize endothelial dysfunction or oxidative stress. However, a combination of insulin and vitamin C normalized enclothelial dysfunction and decreased oxidative stress to normal levels. CONCLUSIONS - This study suggests that long-lasting hyperglycemia in type I diabetic patients induces permanent alterations in endothelial cells, which may contribute to endothelial dysfunction by increased oxidative stress even when hyperglycemia is normalized.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine|
|Divisions:||Faculty of Medicine > Warwick Medical School|
|Journal or Publication Title:||Diabetes Care|
|Publisher:||American Diabetes Association|
|Number of Pages:||6|
|Page Range:||pp. 649-654|
|Access rights to Published version:||Restricted or Subscription Access|
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