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EDM2 is required for RPP7-dependent disease resistance in Arabidopsis and affects RPP7 transcript levels
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Eulgem, Thomas, Tsuchiya, Tokuji, Wang, Xiao-Jun, Beasley, Britt, Cuzick, Alayne, Tör, Mahmut, Zhu, Tong, McDowell, John M., Holub, E. B. and Dangl, J. L. (Jeffery L.). (2007) EDM2 is required for RPP7-dependent disease resistance in Arabidopsis and affects RPP7 transcript levels. Plant Journal, Vol.49 (No.5). pp. 829-839. ISSN 0960-7412
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Official URL: http://dx.doi.org/10.1111/j.1365-313X.2006.02999.x
Abstract
Specific disease resistance of Arabidopsis thaliana against the Hyaloperonospora parasitica isolate Hiks1 (HpHiks1) is mediated by RPP7. Although this disease resistance gene encodes a typical nucleotide binding site leucine-rich repeat (NB-LRR) disease resistance protein, its function is independent of the defense hormone salicylic acid and most known genes required for plant immune responses. We identified EDM2 (enhanced downy mildew 2) in a genetic screen for RPP7 suppressors. Mutations of EDM2 phenocopy RPP7 mutations, but do not affect other tested disease resistance genes. We isolated EDM2 by map-based cloning. The predicted EDM2 protein is structurally unrelated to previously identified components of the plant immune system, bears typical features of transcriptional regulators, including plant homeodomain (PHD)-finger-like domains, and defines a plant-specific protein family. In edm2 mutants both constitutive and HpHiks1-induced RPP7 transcript levels are reduced, suggesting that EDM2 is either a direct or an indirect regulator of RPP7 expression. Microarray analyses defined a set of defense-associated genes, the expression of which is suppressed during successful HpHiks1 colonization of either rpp7 or edm2 plants. This transcriptional phenotype is counteracted by an EDM2/RPP7-dependent mechanism.
| Item Type: | Journal Article |
|---|---|
| Subjects: | S Agriculture > SB Plant culture |
| Divisions: | Faculty of Science > Life Sciences (2010- ) > Warwick HRI (2004-2010) |
| Journal or Publication Title: | Plant Journal |
| Publisher: | Blackwell |
| ISSN: | 0960-7412 |
| Date: | March 2007 |
| Volume: | Vol.49 |
| Number: | No.5 |
| Number of Pages: | 11 |
| Page Range: | pp. 829-839 |
| Identification Number: | 10.1111/j.1365-313X.2006.02999.x |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/32359 |
Data sourced from Thomson Reuters' Web of Knowledge
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