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An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-ToF instrument

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Pringle, Steven D., Giles, Kevin, Wildgoose, Jason L., Williams, Jonathan P., Slade, Susan E., Thalassinos, Konstantinos, Bateman, Robert H., Bowers, Michael T. and Scrivens, James H. (2007) An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-ToF instrument. International Journal of Mass Spectrometry, Vol.261 (No.1). pp. 1-12. doi:10.1016/j.ijms.2006.07.021

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Official URL: http://dx.doi.org/10.1016/j.ijms.2006.07.021

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Abstract

Ion mobility coupled with mass spectrometry has evolved into a powerful analytical technique for investigating the gas-phase structures of biomolecules. Here we present the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave ion mobility separator/orthogonal acceleration time-of-flight instrument. Comparison of the mobility data obtained from the relatively new travelling wave separation device with data obtained using various other mobility separators demonstrate that whilst the mobility characteristics are similar, the new hybrid instrument geometry provides mobility separation without compromising the base sensitivity of the mass spectrometer. This capability facilitates mobility studies of samples at analytically significant levels. (C) 2006 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Subjects: Q Science > QC Physics
Divisions: Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Journal or Publication Title: International Journal of Mass Spectrometry
Publisher: Elsevier BV
ISSN: 1387-3806
Official Date: 1 March 2007
Dates:
DateEvent
1 March 2007Published
Volume: Vol.261
Number: No.1
Number of Pages: 12
Page Range: pp. 1-12
DOI: 10.1016/j.ijms.2006.07.021
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

Data sourced from Thomson Reuters' Web of Knowledge

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