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An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-ToF instrument
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Pringle, Steven D., Giles, Kevin, Wildgoose, Jason L., Williams, Jonathan P., Slade, Susan E., Thalassinos, Konstantinos, Bateman, Robert H., Bowers, Michael T. and Scrivens, James H. (2007) An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-ToF instrument. International Journal of Mass Spectrometry, Vol.261 (No.1). pp. 1-12. doi:10.1016/j.ijms.2006.07.021
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Official URL: http://dx.doi.org/10.1016/j.ijms.2006.07.021
Abstract
Ion mobility coupled with mass spectrometry has evolved into a powerful analytical technique for investigating the gas-phase structures of biomolecules. Here we present the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave ion mobility separator/orthogonal acceleration time-of-flight instrument. Comparison of the mobility data obtained from the relatively new travelling wave separation device with data obtained using various other mobility separators demonstrate that whilst the mobility characteristics are similar, the new hybrid instrument geometry provides mobility separation without compromising the base sensitivity of the mass spectrometer. This capability facilitates mobility studies of samples at analytically significant levels. (C) 2006 Elsevier B.V. All rights reserved.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QC Physics | ||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010) | ||||
| Journal or Publication Title: | International Journal of Mass Spectrometry | ||||
| Publisher: | Elsevier BV | ||||
| ISSN: | 1387-3806 | ||||
| Official Date: | 1 March 2007 | ||||
| Dates: |
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| Volume: | Vol.261 | ||||
| Number: | No.1 | ||||
| Number of Pages: | 12 | ||||
| Page Range: | pp. 1-12 | ||||
| DOI: | 10.1016/j.ijms.2006.07.021 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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