The role of sodium channels in neuropathic pain
Rogers, Marc, Tang, Lam, Madge, David J. and Stevens, Edward B. (2006) The role of sodium channels in neuropathic pain. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 17 (5). pp. 571-581. ISSN 1084-9521Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.semedb.2006.10.009
Our knowledge of the ion channels, receptors and signalling mechanisms involved in pain pathophysiology, and which specific channels play a role in subtypes of pain such as neuropathic and inflammatory pain, has expanded considerably in recent years. It is now clear that in the neuropathic state the expression of certain channels is modified, and that these changes underlie the plasticity of responses that occur to generate inappropriate pain signals from normally trivial inputs. Pain is modulated by a subset of the voltage-gated sodium channels, including Nav1.3, Nav1.7, Nav1.8 and Nav1.9. These isoforms display unique expression patterns within specific tissues, and are either up- or down-regulated upon injury to the nervous system. Here we describe our current understanding of the roles of sodium channels in pain and nociceptive information processing, with a particular emphasis on neuropathic pain and drugs useful for the treatment of neuropathic pain that act through mechanisms involving block of sodium channels. One of the future challenges in the development of novel sodium channel blockers is to design and synthesise isoform-selective channel inhibitors. This should provide substantial benefits over existing pain treatments. (c) 2006 Elsevier Ltd. All rights reserved.
|Item Type:||Journal Item|
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Journal or Publication Title:||SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY|
|Publisher:||ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD|
|Number of Pages:||11|
|Page Range:||pp. 571-581|
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