Watson, Peter and Spooner, Robert A. (2006) Toxin entry and trafficking in mammalian cells. Advanced Drug Delivery Reviews, Vol.58 (No.15). pp. 1581-1596. ISSN 0169-409X

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Abstract

There is a vast number of bacterial and plant toxins that affect cytosolic targets in mammalian cells, and whether the purpose of the toxin is to act as a defence mechanism against predators, or to cause deliberate cell death in order to form an environment more suitable for bacterial growth, each of these toxins must cross a lipid membrane barrier in order to exert their effect. This review looks at the methods employed by bacterial and plant toxins in order to reach their target. We examine the trafficking methods involved in toxin transport throughout the cell, highlighting the proteins necessary for the toxins movement, and noting how many of the toxins hijack the cells own trafficking and protein processing machinery in order to reach their goals. Studying the trafficking of toxins has led to a greater understanding of retrograde transport, a process which has key relevance to the correct intracellular delivery of pharmacological agents. (c) 2006 Elsevier B.V. All rights reserved.

Item Type:	Journal Item
Subjects:	R Medicine > RS Pharmacy and materia medica
Journal or Publication Title:	Advanced Drug Delivery Reviews
Publisher:	Elsevier BV
ISSN:	0169-409X
Date:	30 December 2006
Volume:	Vol.58
Number:	No.15
Number of Pages:	16
Page Range:	pp. 1581-1596
Identification Number:	10.1016/j.addr.2006.09.016
Status:	Peer Reviewed
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/32567

Data sourced from Thomson Reuters' Web of Knowledge

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