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Quality control: Linking retrotranslocation and degradation
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Stirling, Colin J. and Lord, Mike (2006) Quality control: Linking retrotranslocation and degradation. CURRENT BIOLOGY, 16 (24). R1035-R1037. doi:10.1016/j.cub.2006.11.013
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Official URL: http://dx.doi.org/10.1016/j.cub.2006.11.013
Abstract
Misfolded proteins in the ER require the p97 AAA ATPase for dislocation across the membrane prior to degradation by the cytosolic proteasome. The mechanism by which dislocated proteins are delivered to the proteasome from p97 is unclear, but recent studies suggest an important regulatory role for the protein ataxin-3.
Item Type: | Journal Item | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Journal or Publication Title: | CURRENT BIOLOGY | ||||
Publisher: | CELL PRESS | ||||
ISSN: | 0960-9822 | ||||
Official Date: | 19 December 2006 | ||||
Dates: |
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Volume: | 16 | ||||
Number: | 24 | ||||
Number of Pages: | 3 | ||||
Page Range: | R1035-R1037 | ||||
DOI: | 10.1016/j.cub.2006.11.013 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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