Baines, Richard A.. (2006) Development of motoneuron electrical properties and motor output. International Review of Neurobiology, Volume 75 . pp. 91-103. ISSN 0074-7742

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Abstract

This chapter discusses a series of studies that apply whole-cell patch clamp recordings to embryonic Drosophila motoneurons in vivo. These studies not only chart the electrical development of these neurons, from the first onset of electrical activity to maturity, but also show that synaptogenesis and synaptic plasticity in the central nervous system (CNS) are reliant on mechanisms remarkably similar to those that operate at the neuromuscular junction (NMJ). Postembryonic development of the NMJ is critically dependent on both the relative levels and localization of the cell adhesion molecule FasciclinII (FasII). Technical advances make possible the application of relatively sophisticated electrophysiology to the CNS of Drosophila embryos and larvae. The comparatively few studies that have applied such techniques provide compelling evidence to show that the development of central motoneurons, together with the molecular mechanisms that govern synaptic growth and plasticity, are remarkably similar to those already shown to operate at the NMJ.

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Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Journal or Publication Title:	International Review of Neurobiology
Publisher:	Academic Press
ISSN:	0074-7742
Book Title:	The Fly Neuromuscular Junction: Structure and Function Second Edition
Date:	2006
Volume:	Volume 75
Number of Pages:	13
Page Range:	pp. 91-103
Identification Number:	10.1016/S0074-7742(06)75005-X
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/32611

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