Zoumakis, E., Grammatopoulos, D. K. and Chrousos, G. P. (2006) Corticotropin-releasing hormone receptor antagonists. In: 4th Ferring Pharmaceuticals International Paediatric Endocrinology Symposium, Paris, FRANCE, 2006. Published in: EUROPEAN JOURNAL OF ENDOCRINOLOGY, 155 (Suppl. 1). S85-S91.

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Abstract

Corticotropin-releasing hormone (CRH), CRH-related peptides, and CRH receptors play major roles in coordinating the behavioral, endocrine, autonomic, and immune responses to stress. The wide influence of the CRH system on physiological processes in both brain and periphery implicates the respective peptides in the pathophysiology of numerous disorders characterized by dysregulated stress responses. The potential use of CRH antagonists is presently under intense investigation. Selective antagonists have been used experimentally to elucidate the role of CRH-related peptides in disease processes, such as anxiety and depression, sleep disorders, addictive behavior, inflammatory disorders, acute and chronic neurodegeneration, and preterm labor.

Item Type:	Conference Item (UNSPECIFIED)
Subjects:	R Medicine > RC Internal medicine
Journal or Publication Title:	EUROPEAN JOURNAL OF ENDOCRINOLOGY
Publisher:	BIO SCIENTIFICA LTD
ISSN:	0804-4643
Official Date:	November 2006
Volume:	155
Number:	Suppl. 1
Number of Pages:	7
Page Range:	S85-S91
Identification Number:	10.1530/eje.1.02259
Publication Status:	Published
Title of Event:	4th Ferring Pharmaceuticals International Paediatric Endocrinology Symposium
Location of Event:	Paris, FRANCE
Date(s) of Event:	2006
URI:	http://wrap.warwick.ac.uk/id/eprint/32613

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