Gilardini, Luisa, McTernan, P. G. (Philip G.), Girola, Andrea, da Silva, Nancy F., Alberti, Luisella, Kumar, Sudhesh and Invitti, Cecilia. (2006) Adiponectin is a candidate marker of metabolic syndrome in obese children and adolescents. ATHEROSCLEROSIS, 189 (2). pp. 401-407. ISSN 0021-9150

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Abstract

The aim of this study was to compare the use of several biomarkers to identify obese children and adolescents with increased metabolic risk. One hundred sixty-two Caucasian obese children and adolescents (41% males, 9-18 years old) referred to the Istituto Auxologico Italiano between 2003 and 2004 underwent an oral glucose tolerance test. Circulating levels of adiponectin (AD), plasminogen activator inhibitor I (PAI-1), interleukin 18 (IL-18), C-reactive protein (CRP), fibrinogen, uric acid, lipids and insulin were measured. Twenty five percent of obese children had the MS defined using World Health Organization-derived child specific criteria. MS subjects had significantly lower AD (p < 0.01) and higher log-PAI-I (p < 0.001), uric acid (p < 0.0001), and IL-18 (p < 0.001). Subjects with AD levels <= median value had a significantly increased risk of having the MS (p < 0.0001), as did subjects with uric acid and PAI-1 levels greater than the median. There was no increased risk with elevated IL-18, CRP, or fibrinogen. Hypoadiponectmemia was independently associated with the MS risk (p < 0.0001). In conclusion in obese children and adolescents AD is the best predictor of MS and thus of higher cardiovascular disease risk. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine
Journal or Publication Title:	ATHEROSCLEROSIS
Publisher:	ELSEVIER IRELAND LTD
ISSN:	0021-9150
Date:	December 2006
Volume:	189
Number:	2
Number of Pages:	7
Page Range:	pp. 401-407
Identification Number:	10.1016/j.atherosclerosis.2005.12.021
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/32764

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