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Adiponectin is a candidate marker of metabolic syndrome in obese children and adolescents
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Gilardini, Luisa, McTernan, P. G. (Philip G.), Girola, Andrea, da Silva, Nancy F., Alberti, Luisella, Kumar, Sudhesh and Invitti, Cecilia (2006) Adiponectin is a candidate marker of metabolic syndrome in obese children and adolescents. Atherosclerosis, Volume 189 (Number 2). pp. 401-407. doi:10.1016/j.atherosclerosis.2005.12.021 ISSN 0021-9150.
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Official URL: http://dx.doi.org/10.1016/j.atherosclerosis.2005.1...
Abstract
The aim of this study was to compare the use of several biomarkers to identify obese children and adolescents with increased metabolic risk. One hundred sixty-two Caucasian obese children and adolescents (41% males, 9-18 years old) referred to the Istituto Auxologico Italiano between 2003 and 2004 underwent an oral glucose tolerance test. Circulating levels of adiponectin (AD), plasminogen activator inhibitor I (PAI-1), interleukin 18 (IL-18), C-reactive protein (CRP), fibrinogen, uric acid, lipids and insulin were measured. Twenty five percent of obese children had the MS defined using World Health Organization-derived child specific criteria. MS subjects had significantly lower AD (p < 0.01) and higher log-PAI-I (p < 0.001), uric acid (p < 0.0001), and IL-18 (p < 0.001). Subjects with AD levels <= median value had a significantly increased risk of having the MS (p < 0.0001), as did subjects with uric acid and PAI-1 levels greater than the median. There was no increased risk with elevated IL-18, CRP, or fibrinogen. Hypoadiponectmemia was independently associated with the MS risk (p < 0.0001). In conclusion in obese children and adolescents AD is the best predictor of MS and thus of higher cardiovascular disease risk. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RC Internal medicine | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Journal or Publication Title: | Atherosclerosis | ||||
Publisher: | Elsevier Ireland Ltd. | ||||
ISSN: | 0021-9150 | ||||
Official Date: | December 2006 | ||||
Dates: |
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Volume: | Volume 189 | ||||
Number: | Number 2 | ||||
Number of Pages: | 7 | ||||
Page Range: | pp. 401-407 | ||||
DOI: | 10.1016/j.atherosclerosis.2005.12.021 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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