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Postprandial hyperglycaemia and cardiovascular complications of diabetes: An update
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Ceriello, Antonio, Davidson, Jamie, Hanefeld, Markolf, Leiter, Lawrence, Monnier, Louis, Owens, David, Tajima, Naoko and Tuomilehto, Jaakko (2006) Postprandial hyperglycaemia and cardiovascular complications of diabetes: An update. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 16 (7). pp. 453-456. ISSN 0939-4753
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Official URL: http://dx.doi.org/10.1016/j.numecd.2006.05.006
Abstract
Type 2 diabetes is characterised by a gradual decline in insulin secretion in response to nutrient loads; hence, it is primarily a disorder of postprandial glucose (PPG) regulation. However, physicians continue to rely on fasting plasma glucose (FPG) and glycosylated haemoglobin (HbA1c) levels as indicators for disease management. There is a linear relationship between the risk of cardiovascular disease (CVD) and the two-hour oral glucose tolerance test (OGTT), while a recent study confirms postprandial hyperglycaemia as an independent risk factor for CVD in type 2 diabetes. At the same time, several intervention studies have shown that treating postprandial hyperglycaemia may reduce the incidence of new cardiovascular events. Evidence supports the hypothesis that postprandial hyperglycaemia may be linked to CVD through the generation of oxidative stress. Furthermore, clinical data suggest that postprandial hyperglycaemia is a common phenomenon, even in patients who may be considered in 'good metabolic control'. Therefore, in addition to HbA1c and FPG, physicians should consider monitoring and targeting PPG in patients with type 2 diabetes. (C) 2006 Elsevier B.V. All rights reserved.
| Item Type: | Journal Item | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QM Human anatomy R Medicine > RC Internal medicine R Medicine > RA Public aspects of medicine |
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| Journal or Publication Title: | NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | ||||
| Publisher: | ELSEVIER SCI LTD | ||||
| ISSN: | 0939-4753 | ||||
| Official Date: | October 2006 | ||||
| Dates: |
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| Volume: | 16 | ||||
| Number: | 7 | ||||
| Number of Pages: | 4 | ||||
| Page Range: | pp. 453-456 | ||||
| Identification Number: | 10.1016/j.numecd.2006.05.006 | ||||
| Publication Status: | Published | ||||
| URI: | http://wrap.warwick.ac.uk/id/eprint/32773 |
Data sourced from Thomson Reuters' Web of Knowledge
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