Ceriello, Antonio, Davidson, Jamie, Hanefeld, Markolf, Leiter, Lawrence, Monnier, Louis, Owens, David, Tajima, Naoko and Tuomilehto, Jaakko (2006) Postprandial hyperglycaemia and cardiovascular complications of diabetes: An update. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 16 (7). pp. 453-456. ISSN 0939-4753

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Abstract

Type 2 diabetes is characterised by a gradual decline in insulin secretion in response to nutrient loads; hence, it is primarily a disorder of postprandial glucose (PPG) regulation. However, physicians continue to rely on fasting plasma glucose (FPG) and glycosylated haemoglobin (HbA1c) levels as indicators for disease management. There is a linear relationship between the risk of cardiovascular disease (CVD) and the two-hour oral glucose tolerance test (OGTT), while a recent study confirms postprandial hyperglycaemia as an independent risk factor for CVD in type 2 diabetes. At the same time, several intervention studies have shown that treating postprandial hyperglycaemia may reduce the incidence of new cardiovascular events. Evidence supports the hypothesis that postprandial hyperglycaemia may be linked to CVD through the generation of oxidative stress. Furthermore, clinical data suggest that postprandial hyperglycaemia is a common phenomenon, even in patients who may be considered in 'good metabolic control'. Therefore, in addition to HbA1c and FPG, physicians should consider monitoring and targeting PPG in patients with type 2 diabetes. (C) 2006 Elsevier B.V. All rights reserved.

Item Type:	Journal Item
Subjects:	Q Science > QM Human anatomy R Medicine > RC Internal medicine R Medicine > RA Public aspects of medicine
Journal or Publication Title:	NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
Publisher:	ELSEVIER SCI LTD
ISSN:	0939-4753
Date:	October 2006
Volume:	16
Number:	7
Number of Pages:	4
Page Range:	pp. 453-456
Identification Number:	10.1016/j.numecd.2006.05.006
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/32773

Data sourced from Thomson Reuters' Web of Knowledge

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