1. Inoue M, Iwasaki M, Otani T, Sasazuki S, Noda M, et al. (2006) Diabetes
mellitus and the risk of cancer: results from a large-scale population-based cohort
study in Japan. Arch Intern Med 166: 1871–1877.
2. Stattin P, Bjor O, Ferrari P, Lukanova A, Lenner P, et al. (2007) Prospective
study of hyperglycemia and cancer risk. Diabetes Care 30: 561–567.
3. Rousseau MC, Parent ME, Pollak MN, Siemiatycki J (2006) Diabetes mellitus
and cancer risk in a population-based case-control study among men from
Montreal, Canada. Int J Cancer 118: 2105–2109.
4. Kasper JS, Giovannucci E (2006) A meta-analysis of diabetes mellitus and the
risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 15: 2056–2062.
5. Gong Z, Neuhouser ML, Goodman PJ, Albanes D, Chi C, et al. (2006) Obesity,
diabetes, and risk of prostate cancer: results from the prostate cancer prevention
trial. Cancer Epidemiol Biomarkers Prev 15: 1977–1983.
6. Calton BA, Chang SC, Wright ME, Kipnis V, Lawson K, et al. (2007) History of
diabetes mellitus and subsequent prostate cancer risk in the NIH-AARP Diet
and Health Study. Cancer Causes Control 18: 493–503.
7. Will JC, Vinicor F, Calle EE (1999) Is diabetes mellitus associated with prostate
cancer incidence and survival? Epidemiology 10: 313–318.
8. Manolio TA, Brooks LD, Collins FS (2008) A HapMap harvest of insights into
the genetics of common disease. J Clin Invest 118: 1590–1605.
9. Gudmundsson J, Sulem P, Steinthorsdottir V, Bergthorsson JT, Thorleifsson G,
et al. (2007) Two variants on chromosome 17 confer prostate cancer risk, and
the one in TCF2 protects against type 2 diabetes. Nat Genet 39: 977–983.
10. Sun J, Zheng SL, Wiklund F, Isaacs SD, Purcell LD, et al. (2008) Evidence for
two independent prostate cancer risk-associated loci in the HNF1B gene at
17q12. Nat Genet 40: 1153–1155.
11. Thomas G, Jacobs KB, Yeager M, Kraft P, Wacholder S, et al. (2008) Multiple
loci identified in a genome-wide association study of prostate cancer. Nat Genet.
12. Winckler W, Weedon MN, Graham RR, McCarroll SA, Purcell S, et al. (2007)
Evaluation of common variants in the six known maturity-onset diabetes of the
young (MODY) genes for association with type 2 diabetes. Diabetes 56:
685–693.
13. Horikawa Y, Iwasaki N, Hara M, Furuta H, Hinokio Y, et al. (1997) Mutation in
hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODY. Nat
Genet 17: 384–385.
14. Tenesa A, Farrington SM, Prendergast JG, Porteous ME, Walker M, et al.
(2008) Genome-wide association scan identifies a colorectal cancer susceptibility
locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet 40:
631–637.
15. Gold B, Kirchhoff T, Stefanov S, Lautenberger J, Viale A, et al. (2008) Genomewide
association study provides evidence for a breast cancer risk locus at
6q22.33. Proc Natl Acad Sci U S A 105: 4340–4345.
16. Maris JM, Mosse YP, Bradfield JP, Hou C, Monni S, et al. (2008) Chromosome
6p22 locus associated with clinically aggressive neuroblastoma. N Engl J Med
358: 2585–2593.
17. Cust AE, Schmid H, Maskiell JA, Jetann J, Ferguson M, et al. (2009) Populationbased,
case-control-family design to investigate genetic and environmental
influences on melanoma risk: Australian Melanoma Family Study.
Am J Epidemiol 170: 1541–1554.
18. Eeles RA, Kote-Jarai Z, Giles GG, Olama AA, Guy M, et al. (2008) Multiple
newly identified loci associated with prostate cancer susceptibility. Nat Genet 40:
316–321.
19. Petersen GM, Amundadottir L, Fuchs CS, Kraft P, Stolzenberg-Solomon RZ,
et al. (2010) A genome-wide association study identifies pancreatic cancer
susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet 42:
224–228.
20. Brennan P, McKay J, Moore L, Zaridze D, Mukeria A, et al. (2007) Uncommon
CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case
control study. Hum Mol Genet 16: 1794–1801.
21. Hung RJ, McKay JD, Gaborieau V, Boffetta P, Hashibe M, et al. (2008) A
susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor
subunit genes on 15q25. Nature 452: 633–637.
22. Amos CI, Wu X, Broderick P, Gorlov IP, Gu J, et al. (2008) Genome-wide
association scan of tag SNPs identifies a susceptibility locus for lung cancer at
15q25.1. Nat Genet 40: 616–622.
23. Zanke BW, Greenwood CM, Rangrej J, Kustra R, Tenesa A, et al. (2007)
Genome-wide association scan identifies a colorectal cancer susceptibility locus
on chromosome 8q24. Nat Genet 39: 989–994.
24. Brown KM, Macgregor S, Montgomery GW, Craig DW, Zhao ZZ, et al. (2008)
Common sequence variants on 20q11.22 confer melanoma susceptibility. Nat
Genet 40: 838–840.
25. Yeager M, Orr N, Hayes RB, Jacobs KB, Kraft P, et al. (2007) Genome-wide
association study of prostate cancer identifies a second risk locus at 8q24. Nat
Genet 39: 645–649.
26. Duggan D, Zheng SL, Knowlton M, Benitez D, Dimitrov L, et al. (2007) Two
genome-wide association studies of aggressive prostate cancer implicate
putative prostate tumor suppressor gene DAB2IP. J Natl Cancer Inst 99:
1836–1844.
27. Tomlinson IP, Webb E, Carvajal-Carmona L, Broderick P, Howarth K, et al.
(2008) A genome-wide association study identifies colorectal cancer susceptibility
loci on chromosomes 10p14 and 8q23.3. Nat Genet 40: 623–630.
28. Stacey SN, Manolescu A, Sulem P, Thorlacius S, Gudjonsson SA, et al. (2008)
Common variants on chromosome 5p12 confer susceptibility to estrogen
receptor-positive breast cancer. Nat Genet 40: 703–706.
29. Rafnar T, Sulem P, Stacey SN, Geller F, Gudmundsson J, et al. (2009) Sequence
variants at the TERT-CLPTM1L locus associate with many cancer types. Nat
Genet 41: 221–227.
30. Thorgeirsson TE, Geller F, Sulem P, Rafnar T, Wiste A, et al. (2008) A variant
associated with nicotine dependence, lung cancer and peripheral arterial disease.
Nature 452: 638–642.
31. Gudmundsson J, Sulem P, Manolescu A, Amundadottir LT, Gudbjartsson D,
et al. (2007) Genome-wide association study identifies a second prostate cancer
susceptibility variant at 8q24. Nat Genet 39: 631–637.
32. Gudmundsson J, Sulem P, Rafnar T, Bergthorsson JT, Manolescu A, et al.
(2008) Common sequence variants on 2p15 and Xp11.22 confer susceptibility to
prostate cancer. Nat Genet.
33. Easton DF, Pooley KA, Dunning AM, Pharoah PD, Thompson D, et al. (2007)
Genome-wide association study identifies novel breast cancer susceptibility loci.
Nature 447: 1087–1093.
34. http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000007.
v9.p4.
35. Edghill EL, Bingham C, Ellard S, Hattersley AT (2006) Mutations in hepatocyte
nuclear factor-1beta and their related phenotypes. J Med Genet 43: 84–90.
36. Rebouissou S, Vasiliu V, Thomas C, Bellanne-Chantelot C, Bui H, et al. (2005)
Germline hepatocyte nuclear factor 1alpha and 1beta mutations in renal cell
carcinomas. Hum Mol Genet 14: 603–614.
37. Reber M, Cereghini S (2001) Variant hepatocyte nuclear factor 1 expression in
the mouse genital tract. Mech Dev 100: 75–78.
38. Coffinier C, Barra J, Babinet C, Yaniv M (1999) Expression of the vHNF1/
HNF1beta homeoprotein gene during mouse organogenesis. Mech Dev 89:
211–213.
39. Ioannidis JP, Thomas G, Daly MJ (2009) Validating, augmenting and refining
genome-wide association signals. Nat Rev Genet 10: 318–329.
40. Yamada H, Penney KL, Takahashi H, Katoh T, Yamano Y, et al. (2009)
Replication of prostate cancer risk loci in a Japanese case-control association
study. J Natl Cancer Inst 101: 1330–1336.
41. Levin AM, Machiela MJ, Zuhlke KA, Ray AM, Cooney KA, et al. (2008)
Chromosome 17q12 variants contribute to risk of early-onset prostate cancer.
Cancer Res 68: 6492–6495.
42. Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, et al. (2008) Metaanalysis
of genome-wide association data and large-scale replication identifies
additional susceptibility loci for type 2 diabetes. Nat Genet 40: 638–645.
43. Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, et al. (2007)
Replication of genome-wide association signals in UK samples reveals risk loci
for type 2 diabetes. Science 316: 1336–1341.
44. Hindorff LA, Sethupathy P, Junkins HA, Ramos EM, Mehta JP, et al. (2009)
Potential etiologic and functional implications of genome-wide association loci
for human diseases and traits. Proc Natl Acad Sci U S A 106: 9362–9367.
45. Kavvoura FK, Ioannidis JP (2008) Methods for meta-analysis in genetic
association studies: a review of their potential and pitfalls. Hum Genet 123:
1–14.
46. Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring
inconsistency in meta-analyses. Bmj 327: 557–560.
47. Ioannidis JP, Patsopoulos NA, Evangelou E (2007) Uncertainty in heterogeneity
estimates in meta-analyses. Bmj 335: 914–916.
48. Petersen GM, Amundadottir L, Fuchs CS, Kraft P, Stolzenberg-Solomon RZ,
et al. A genome-wide association study identifies pancreatic cancer susceptibility
loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet.