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The use of advanced diffraction methods in the study of the structure of a bioactive calcia: silica sol-gel glass
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Newport, Robert John, Skipper, Laura J., Carta, Daniela, Pickup, David M., Sowrey, Frank E., Smith, Mark E., Saravanapavan, Priya and Hench, Larry L. (2006) The use of advanced diffraction methods in the study of the structure of a bioactive calcia: silica sol-gel glass. In: 1985 ANNUAL CONVENTION OF THE AMERICAN PSYCHOLOGICAL ASSOC, LOS ANGELES, CA, 1985. Published in: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 17 (11). pp. 1003-1010.
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Official URL: http://dx.doi.org/10.1007/s10856-006-0436-8
Abstract
Sol-gel derived calcium silicate glasses may be useful for the regeneration of damaged bone. The mechanism of bioactivity is as yet only partially understood but has been strongly linked to calcium dissolution from the glass matrix. In addition to the usual laboratory-based characterisation methods, we have used neutron diffraction with isotopic substitution to gain new insights into the nature of the atomic-scale calcium environment in bioactive sol-gel glasses, and have also used high energy X-ray total diffraction to probe the nature of the processes initiated when bioactive glass is immersed in vitro in simulated body fluid. The data obtained point to a complex calcium environment in which calcium is loosely bound within the glass network and may therefore be regarded as facile. Complex multi-stage dissolution and mineral growth phases were observed as a function of reaction time between 1 min and 30 days, leading eventually, via octacalcium phosphate, to the formation of a disordered hydroxyapatite (HA) layer on the glass surface. This methodology provides insight into the structure of key sites in these materials and key stages involved in their reactions, and thereby more generally into the behaviour of bone-regenerative materials that may facilitate improvements in tissue engineering applications.
| Item Type: | Conference Item (UNSPECIFIED) |
|---|---|
| Subjects: | R Medicine |
| Journal or Publication Title: | JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE |
| Publisher: | SPRINGER |
| ISSN: | 0957-4530 |
| Date: | November 2006 |
| Volume: | 17 |
| Number: | 11 |
| Number of Pages: | 8 |
| Page Range: | pp. 1003-1010 |
| Identification Number: | 10.1007/s10856-006-0436-8 |
| Publication Status: | Published |
| Title of Event: | 1985 ANNUAL CONVENTION OF THE AMERICAN PSYCHOLOGICAL ASSOC |
| Location of Event: | LOS ANGELES, CA |
| Date(s) of Event: | 1985 |
| URI: | http://wrap.warwick.ac.uk/id/eprint/32780 |
Data sourced from Thomson Reuters' Web of Knowledge
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