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Stimulation of pneumovirus-specific CD8(+) T-cells using a non-toxic recombinant ricin delivery system
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Grimaldi, Elizabeth, Claassen, Erwin A. W., Lord, Mike, Smith, Daniel C. and Easton, A. J. (Andrew J.) (2007) Stimulation of pneumovirus-specific CD8(+) T-cells using a non-toxic recombinant ricin delivery system. Molecular Immunology, Vol.44 (No.5). pp. 993-998. doi:10.1016/j.molimm.2006.03.008 ISSN 0161-5890.
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Official URL: http://dx.doi.org/10.1016/j.molimm.2006.03.008
Abstract
Internalisation of the plant toxin ricin occurs by retrograde transport which delivers the toxin to the ER where it intersects with the MHC class I system for peptide antigen display. Here, we describe the generation of an inactivated, non-toxic, ricin molecule fused to a peptide which elicits a CD8(+) T-cell response in mice directed against pneumonia virus of mice, a pneumovirus related to human respiratory syncytial virus. The ricin fusion elicited a significant T-cell response when delivered by intraperitoneal inoculation in the absence of adjuvent. Challenge experiments showed that the T-cell response resulting from inoculation with the ricin-peptide fusion molecule delayed the onset of virus-induced disease. (c) 2006 Elsevier Ltd. All rights reserved.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry Q Science > QR Microbiology > QR180 Immunology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) | ||||
Journal or Publication Title: | Molecular Immunology | ||||
Publisher: | Elsevier | ||||
ISSN: | 0161-5890 | ||||
Official Date: | February 2007 | ||||
Dates: |
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Volume: | Vol.44 | ||||
Number: | No.5 | ||||
Number of Pages: | 6 | ||||
Page Range: | pp. 993-998 | ||||
DOI: | 10.1016/j.molimm.2006.03.008 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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