Grimaldi, Elizabeth, Claassen, Erwin A. W., Lord, Mike (J. Mike), Smith, Daniel C. and Easton, A. J. (Andrew J.). (2007) Stimulation of pneumovirus-specific CD8(+) T-cells using a non-toxic recombinant ricin delivery system. Molecular Immunology, Vol.44 (No.5). pp. 993-998. ISSN 0161-5890

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Abstract

Internalisation of the plant toxin ricin occurs by retrograde transport which delivers the toxin to the ER where it intersects with the MHC class I system for peptide antigen display. Here, we describe the generation of an inactivated, non-toxic, ricin molecule fused to a peptide which elicits a CD8(+) T-cell response in mice directed against pneumonia virus of mice, a pneumovirus related to human respiratory syncytial virus. The ricin fusion elicited a significant T-cell response when delivered by intraperitoneal inoculation in the absence of adjuvent. Challenge experiments showed that the T-cell response resulting from inoculation with the ricin-peptide fusion molecule delayed the onset of virus-induced disease. (c) 2006 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry Q Science > QR Microbiology > QR180 Immunology
Divisions:	Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Journal or Publication Title:	Molecular Immunology
Publisher:	Elsevier
ISSN:	0161-5890
Date:	February 2007
Volume:	Vol.44
Number:	No.5
Number of Pages:	6
Page Range:	pp. 993-998
Identification Number:	10.1016/j.molimm.2006.03.008
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/32806

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