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Regulation of pancreatic beta cell function and viability by adiponectin

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Brown, J. E. P., Digby, J. E., Ward, K. L., Randeva, Harpal S. and Dunmore, S. J. (2006) Regulation of pancreatic beta cell function and viability by adiponectin. In: 42nd Annual Meeting of the European Association for the Study of Diabetes (EASD), Copenhagen, Denmark; Malmoe, Sweden, Sep 14-17, 2006. Published in: Diabetologia, Vol.49 (Suppl.1). pp. 381-382. ISSN 0012-186X.

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Abstract

Obesity is a risk factor for the metabolic syndrome and type 2 diabetes. Adiponectin, a 30kDa adipocyte secreted peptide has been shown to be anti-atherogenic, and anti-inflammatory, as well as affecting insulin resistance and pancreatic beta-cell function. This study investigated the effects of full length and globular adiponectin on pancreatic beta-cell viability, and expression of UCP-2, PDX-1 and LPL genes, as well as studying levels of expression of the adiponectin receptor subtypes 1 and 2 (AdR-1 and AdR-2) and their regulation in the pancreatic BRIN-BD11 beta-cell line.

Item Type: Conference Item (Paper)
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Diabetologia
Publisher: Springer
ISSN: 0012-186X
Official Date: September 2006
Dates:
DateEvent
September 2006Published
Volume: Vol.49
Number: Suppl.1
Number of Pages: 2
Page Range: pp. 381-382
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: European Association for the Study of Diabetes
Conference Paper Type: Paper
Title of Event: 42nd Annual Meeting of the European Association for the Study of Diabetes (EASD)
Type of Event: Conference
Location of Event: Copenhagen, Denmark; Malmoe, Sweden
Date(s) of Event: Sep 14-17, 2006

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