Brown, J. E. P., Digby, J. E., Ward, K. L., Randeva, Harpal S. and Dunmore, S. J. (2006) Regulation of pancreatic beta cell function and viability by adiponectin. In: 42nd Annual Meeting of the European Association for the Study of Diabetes (EASD), Copenhagen, Denmark; Malmoe, Sweden, Sep 14-17, 2006. Published in: Diabetologia, Vol.49 (Suppl.1). pp. 381-382.

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Abstract

Obesity is a risk factor for the metabolic syndrome and type 2 diabetes. Adiponectin, a 30kDa adipocyte secreted peptide has been shown to be anti-atherogenic, and anti-inflammatory, as well as affecting insulin resistance and pancreatic beta-cell function. This study investigated the effects of full length and globular adiponectin on pancreatic beta-cell viability, and expression of UCP-2, PDX-1 and LPL genes, as well as studying levels of expression of the adiponectin receptor subtypes 1 and 2 (AdR-1 and AdR-2) and their regulation in the pancreatic BRIN-BD11 beta-cell line.

Item Type:	Conference Item (Paper)
Subjects:	R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Biomedical Cell Biology Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Diabetologia
Publisher:	Springer
ISSN:	0012-186X
Date:	September 2006
Volume:	Vol.49
Number:	Suppl.1
Number of Pages:	2
Page Range:	pp. 381-382
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	European Association for the Study of Diabetes
Conference Paper Type:	Paper
Title of Event:	42nd Annual Meeting of the European Association for the Study of Diabetes (EASD)
Type of Event:	Conference
Location of Event:	Copenhagen, Denmark; Malmoe, Sweden
Date(s) of Event:	Sep 14-17, 2006
URI:	http://wrap.warwick.ac.uk/id/eprint/32910

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