The Library
Integration of metabolic stimuli in the hypothalamic arcuate nucleus
Tools
van den Top, Marco and Spanswick, David (2006) Integration of metabolic stimuli in the hypothalamic arcuate nucleus. In: 24th International Summer School of Brain Research, Royal Netherlands Acad Arts & Sci, Amsterdam, NETHERLANDS, 29 Aug-01 Sep 2005. Published in: Progress in Brain Research, Volume 153 pp. 141-154. ISBN 0-444-52261-1. doi:10.1016/S0079-6123(06)53008-0 ISSN 0079-6123.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1016/S0079-6123(06)53008-0
Abstract
Integration of peripheral and central anabolic and catabolic inputs within the hypothalamic arcuate nucleus (ARC) is believed to be central to the maintenance of energy balance. In order to perform this complex task, neurons in the ARC express receptors for all major humoral and central transmitters involved in the maintenance of energy homeostasis. The integration of these inputs occurs at the cellular and circuit level and the resulting electrical output forms the origins for the activation of feeding and energy balance-related networks. Here, we discuss the role that active intrinsic membrane conductances, K-ATP channels and intracellular second messenger systems play in the integration of metabolic stimuli at the cellular level in the ARC. We conclude that the research into the integration of hunger and satiety signals in the ARC has made substantial progress in the last decade, but we are far from unraveling the complex neuronal networks involved in the maintenance of energy homeostasis. The diverse range of inputs, neuronal integrative properties, targets, output signals and how these signals relate to the physiological output provides us with a colossal challenge for years to come. However, to battle the current obesity epidemic, target-specific drugs need to be developed for which the knowledge of neuronal pathways involved in the maintenance of energy homeostasis will be crucial.
Item Type: | Conference Item (Paper) | ||||
---|---|---|---|---|---|
Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Series Name: | PROGRESS IN BRAIN RESEARCH | ||||
Journal or Publication Title: | Progress in Brain Research | ||||
Publisher: | Elsevier Science SA | ||||
ISBN: | 0-444-52261-1 | ||||
ISSN: | 0079-6123 | ||||
Editor: | Kalsbeek, A and Fliers, E and Hofman, MA and Swaab, DF and VanSomeren, EJW and Buijs, RM | ||||
Official Date: | 2006 | ||||
Dates: |
|
||||
Volume: | Volume 153 | ||||
Number of Pages: | 14 | ||||
Page Range: | pp. 141-154 | ||||
DOI: | 10.1016/S0079-6123(06)53008-0 | ||||
Status: | Not Peer Reviewed | ||||
Publication Status: | Published | ||||
Conference Paper Type: | Paper | ||||
Title of Event: | 24th International Summer School of Brain Research | ||||
Type of Event: | Other | ||||
Location of Event: | Royal Netherlands Acad Arts & Sci, Amsterdam, NETHERLANDS | ||||
Date(s) of Event: | 29 Aug-01 Sep 2005 |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |