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The Scottish Structural Proteomics Facility : targets, methods and outputs
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(2010) The Scottish Structural Proteomics Facility : targets, methods and outputs. Journal of Structural and Functional Genomics, Vol.11 (No.2). pp. 167-180. doi:10.1007/s10969-010-9090-y
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Official URL: http://dx.doi.org/10.1007/s10969-010-9090-y
Abstract
The Scottish Structural Proteomics Facility was funded to develop a laboratory scale approach to high throughput structure determination. The effort was successful in that over 40 structures were determined. These structures and the methods harnessed to obtain them are reported here. This report reflects on the value of automation but also on the continued requirement for a high degree of scientific and technical expertise. The efficiency of the process poses challenges to the current paradigm of structural analysis and publication. In the 5 year period we published ten peer-reviewed papers reporting structural data arising from the pipeline. Nevertheless, the number of structures solved exceeded our ability to analyse and publish each new finding. By reporting the experimental details and depositing the structures we hope to maximize the impact of the project by allowing others to follow up the relevant biology.
| Item Type: | Submitted Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QP Physiology Q Science > QH Natural history > QH301 Biology |
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| Divisions: | Faculty of Science > Chemistry | ||||
| Library of Congress Subject Headings (LCSH): | Proteomics, Proteins -- Structure, Molecular biology -- Research | ||||
| Journal or Publication Title: | Journal of Structural and Functional Genomics | ||||
| Publisher: | Springer Netherlands | ||||
| ISSN: | 1345-711X | ||||
| Official Date: | June 2010 | ||||
| Dates: |
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| Volume: | Vol.11 | ||||
| Number: | No.2 | ||||
| Page Range: | pp. 167-180 | ||||
| DOI: | 10.1007/s10969-010-9090-y | ||||
| Status: | Peer Reviewed | ||||
| Access rights to Published version: | Open Access | ||||
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Scottish Funding Council (SFC), European Union (EU) | ||||
| Grant number: | SSPF (SFC), SULSA (SFC), BB/S/B14450 (BBSRC), Aeropath (EU) |
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