Ceriello, Antonio (2006) Controlling oxidative stress as a novel molecular approach to protecting the vascular wall in diabetes. CURRENT OPINION IN LIPIDOLOGY, 17 (5). pp. 510-518. ISSN 0957-9672

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Abstract

Purpose of review,In diabetes, oxidative stress plays a key role in the pathogenesis of vascular complications; therefore an antioxidant therapy would be of great interest in this disease.

Recent findings Hyperglycemia directly promotes an endothelial dysfunction - inducing process of overproduction of superoxide at the mitochondrial level. This is the first and key event able to activate all the pathways involved in the development of vascular complications of diabetes. It has recently been shown that statins, angiotensin-converting enzyme inhibitors, angiotensin 11 type 1 blockers, calcium channel blockers, and thiazolidinediones have a strong intracellular antioxidant activity.

Summary Classic antioxidants, such as vitamin E, failed to show beneficial effects on diabetic complications probably because their action is only 'symptomatic'. The preventive activity against hyperglycemia-induced oxidative stress shown by statins, angiotensin-converting enzyme inhibitors, angiotensin 11 type 1 blockers, calcium channel blockers, and thiazolidinediones justifies use of these compounds for preventing complications in, patients with diabetes, in whom antioxidant defences have been shown to be defective.

Item Type:	Journal Item
Subjects:	Q Science > QD Chemistry R Medicine > RC Internal medicine
Journal or Publication Title:	CURRENT OPINION IN LIPIDOLOGY
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
ISSN:	0957-9672
Official Date:	October 2006
Volume:	17
Number:	5
Number of Pages:	9
Page Range:	pp. 510-518
Identification Number:	10.1097/01.mol.0000245256.17764.fb
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/32974

Data sourced from Thomson Reuters' Web of Knowledge

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