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Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2 '-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis

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Stanley, Anna E., Walton, Laura J., Zerikly, Malek Kourdi, Corre, Christophe and Challis, Gregory L. (2006) Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2 '-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis. Chemical Communications (Number 38). pp. 3981-3983. doi:10.1039/b609556a ISSN 1359-7345.

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Official URL: http://dx.doi.org/10.1039/b609556a

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Abstract

The biosynthetic pathway to 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde (MBC), a key intermediate in the biosynthesis of prodiginine antibiotics in Streptomyces coelicolor, has been elucidated using a combination of gene replacements and feeding experiments with chemically synthesised MBC and a synthetic analogue of a pathway intermediate.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Journal or Publication Title: Chemical Communications
Publisher: Royal Society of Chemistry
ISSN: 1359-7345
Official Date: 2006
Dates:
DateEvent
2006Published
Number: Number 38
Number of Pages: 3
Page Range: pp. 3981-3983
DOI: 10.1039/b609556a
Status: Peer Reviewed
Publication Status: Published

Data sourced from Thomson Reuters' Web of Knowledge

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