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Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2 '-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis
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Stanley, Anna E., Walton, Laura J., Zerikly, Malek Kourdi, Corre, Christophe and Challis, Gregory L. (2006) Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2 '-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis. Chemical Communications (Number 38). pp. 3981-3983. doi:10.1039/b609556a ISSN 1359-7345.
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Official URL: http://dx.doi.org/10.1039/b609556a
Abstract
The biosynthetic pathway to 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde (MBC), a key intermediate in the biosynthesis of prodiginine antibiotics in Streptomyces coelicolor, has been elucidated using a combination of gene replacements and feeding experiments with chemically synthesised MBC and a synthetic analogue of a pathway intermediate.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
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| Journal or Publication Title: | Chemical Communications | ||||
| Publisher: | Royal Society of Chemistry | ||||
| ISSN: | 1359-7345 | ||||
| Official Date: | 2006 | ||||
| Dates: |
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| Number: | Number 38 | ||||
| Number of Pages: | 3 | ||||
| Page Range: | pp. 3981-3983 | ||||
| DOI: | 10.1039/b609556a | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published |
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