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Bukowski, Radek, Hankins, Gary D. V., Saade, George R. and Thornton, Steve (2006) Discussion required for correct interpretation. PL o S Medicine, Vol.3 (No.8). p. 1438. ISSN 1549-1277

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Official URL: http://dx.doi.org/10.1371/journal.pmed.0030369

Abstract

Thank you for the opportunity to comment on the editorial by Romero and colleagues [1], which raises a number of important and interesting questions. Such discussion is mandatory if results of scientific techniques such as gene array are to be correctly interpreted and used as the basis for future improvements in patient care.

Item Type:	Journal Item
Subjects:	R Medicine > RG Gynecology and obstetrics
Divisions:	Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Gene expression, Labor (Obstetrics)
Journal or Publication Title:	PL o S Medicine
Publisher:	Public Library of Science
ISSN:	1549-1277
Date:	29 August 2006
Volume:	Vol.3
Number:	No.8
Number of Pages:	1
Page Range:	p. 1438
Identification Number:	10.1371/journal.pmed.0030369
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access
References:	1. Romero R, Tarca AL, Tromp G (2006) Insights into the physiology of childbirth using transcriptomics. PLoS Med 3: e276. DOI: 10.1371/journal. pmed.0030276 2. Challis JRG, Matthews SG, Gibb W, Lye SJ (2000) Endocrine and paracrine regulation of birth at term and preterm. Endocr Rev 21: 514–550. 3. Sparey C, Robson SC, Bailey J, Lyall F, Europe-Finner GN (1999) The differential expression of myometrial connexin-43, cyclooxygenase-1 and -2, and Gs alpha proteins in the upper and lower segments of the human uterus during pregnancy and labor. J Clin Endocrinol Metab 84: 1705–1710. 4. Slater DM, Miles L, Sykes AL, Poston L, Bennett PR (2000) Expression of secretory and cytosolic phospholipase A2 in human myometrium: Changes in relation to gestational age and labour. J Soc Gynecol Investig 7: 129. 5. Chan EC, Fraser S, Yin S, Yeo G, Kwek K, et al. (2002) Human myometrial genes are differentially expressed in labor: A suppression subtractive hybridization study. J Clin Endocrinol Metab 87: 2435–2441. 6. Bethin KE, Nagai Y, Sladek R, Asada M, Sadovsky Y, et al. (2003) Microarray analysis of uterine gene expression in mouse and human pregnancy. Mol Endocrinol 17: 1454–1469. 7. Aguan K, Carvajal JA, Thompson LP, Weiner CP (2000) Application of a functional genomics approach to identify differentially expressed genes in human myometrium during pregnancy and labour. Mol Hum Reprod 6: 1141–1145.
URI:	http://wrap.warwick.ac.uk/id/eprint/33114