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The regulation of adiponectin receptors in human prostate cancer cell lines

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Mistry, T., Digby, J. E., Chen, Jing, Desai, K. M. and Randeva, Harpal S. (2006) The regulation of adiponectin receptors in human prostate cancer cell lines. Biochemical and Biophysical Research Communications, Vol.348 (No.3). pp. 832-838. doi:10.1016/j.bbrc.2006.07.139 ISSN 0006-291X.

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Official URL: http://dx.doi.org/10.1016/j.bbrc.2006.07.139

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Abstract

Obesity is a risk factor for prostate cancer, and plasma levels of the adipokine, adiponectin, are low in the former but high in the latter. Adiponectin has been shown to modulate cell proliferation and apoptosis, suggesting that adiponectin and its receptors (Adipo-R1, Adipo-R2) may provide a molecular association between obesity and prostate carcinogenesis. We show for the first time, the protein distribution of Adipo-R1 and Adipo-R2 in LNCaP and PC3 cells, and in human prostate tissue. Using real-time RTPCR we provide novel data demonstrating the differential regulation of Adipo-R1 and Adipo-R2 mRNA expression by testosterone, 5-alpha dihydrotestosterone, beta-estradiol, tumour necrosis factor-alpha, leptin, and adiponectin in LNCaP and PC3 cells. Our findings suggest that adiponectin and its receptors may contribute to the molecular association between obesity and prostate cancer through a complex interaction with other hormones and cytokines that also play important roles in the pathophysiology of obesity and prostate cancer. (c) 2006 Elsevier Inc. All rights reserved.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Biochemical and Biophysical Research Communications
Publisher: Elsevier
ISSN: 0006-291X
Official Date: 29 September 2006
Dates:
DateEvent
29 September 2006Published
Volume: Vol.348
Number: No.3
Number of Pages: 7
Page Range: pp. 832-838
DOI: 10.1016/j.bbrc.2006.07.139
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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