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Publication bias affected the estimate of postoperative nausea in an acupoint stimulation systematic review
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Lee, Anna, Copas, John B., Henmi, Masayuki, Gin, Tony and Chung, Raymond C. K. (2006) Publication bias affected the estimate of postoperative nausea in an acupoint stimulation systematic review. Journal of Clinical Epidemiology, Volume 59 (Number 9). pp. 980-983. doi:10.1016/j.jclinepi.2006.02.003 ISSN 0895-4356.
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Official URL: http://dx.doi.org/10.1016/j.jclinepi.2006.02.003
Abstract
Background and Objective: To assess the effect of publication bias and country effect on the results and conclusion of a systematic review of wrist P6 acupoint stimulation for the prevention of postoperative nausea and vomiting.
Methods: Reanalysis of a systematic review of 26 randomized trials comparing P6 acupoint stimulation with sham published in the Cochrane Database of Systematic Reviews using the Copas' sensitivity approach.
Results: If it is assumed that all studies that have ever been carried out are included, or that those selected for review are truly representative of all such studies, then the estimated relative risk (RR) for nausea was 0.71 (95% Cl: 0.58 to 0.88, P <.01) and for vomiting was 0.70 (95% Cl: 0.56 to 0.88, P <.01) after adjusting for country effect. For nausea, adjustment for publication bias suggests that the risk has been overestimated. If around 33% of studies have been unpublished, the RR of nausea (0.92, 95% Cl: 0.80 to 1.06, P =.25) is no longer significant. For vomiting, however, there is no strong evidence of publication bias. The number of unpublished studies required to substantially overturn the above significant result is implausibly large.
Conclusion: Publication bias affects the published estimate of postoperative nausea, not vomiting. (c) 2006 Elsevier Inc. All rights reserved.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Statistics | ||||
| Journal or Publication Title: | Journal of Clinical Epidemiology | ||||
| Publisher: | Elsevier Inc. | ||||
| ISSN: | 0895-4356 | ||||
| Official Date: | September 2006 | ||||
| Dates: |
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| Volume: | Volume 59 | ||||
| Number: | Number 9 | ||||
| Number of Pages: | 4 | ||||
| Page Range: | pp. 980-983 | ||||
| DOI: | 10.1016/j.jclinepi.2006.02.003 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
Data sourced from Thomson Reuters' Web of Knowledge
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