Identifying interactions in the time and frequency domains in local and global networks : a Granger causality approach
Zou, Cunlu, Ladroue, Christophe, Guo, Shuixia and Feng, Jianfeng. (2010) Identifying interactions in the time and frequency domains in local and global networks : a Granger causality approach. BMC Bioinformatics, Vol.11 . Article 337. ISSN 1471-2105
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Official URL: http://dx.doi.org/10.1186/1471-2105-11-337
Reverse-engineering approaches such as Bayesian network inference, ordinary differential equations (ODEs) and information theory are widely applied to deriving causal relationships among different elements such as genes, proteins, metabolites, neurons, brain areas and so on, based upon multi-dimensional spatial and temporal data. There are several well-established reverse-engineering approaches to explore causal relationships in a dynamic network, such as ordinary differential equations (ODE), Bayesian networks, information theory and Granger Causality.
Here we focused on Granger causality both in the time and frequency domain and in local and global networks, and applied our approach to experimental data (genes and proteins). For a small gene network, Granger causality outperformed all the other three approaches mentioned above. A global protein network of 812 proteins was reconstructed, using a novel approach. The obtained results fitted well with known experimental findings and predicted many experimentally testable results. In addition to interactions in the time domain, interactions in the frequency domain were also recovered.
The results on the proteomic data and gene data confirm that Granger causality is a simple and accurate approach to recover the network structure. Our approach is general and can be easily applied to other types of temporal data.
|Item Type:||Journal Article|
|Subjects:||Q Science > QA Mathematics
Q Science > QH Natural history > QH426 Genetics
Q Science > QH Natural history > QH301 Biology
|Divisions:||Faculty of Science > Centre for Scientific Computing
Faculty of Science > Computer Science
|Library of Congress Subject Headings (LCSH):||Time-series analysis, Computational biology, Causality (Physics)|
|Journal or Publication Title:||BMC Bioinformatics|
|Publisher:||BioMed Central Ltd.|
|Official Date:||21 June 2010|
|Page Range:||Article 337|
|Access rights to Published version:||Open Access|
|Funder:||Engineering and Physical Sciences Research Council (EPSRC), Guo jia zi ran ke xue ji jin wei yuan hui (China) [National Natural Science Foundation of China] (NSFC), Hunan Provincial Education Department (HPED)|
|Grant number:||EP/E002331/1 (EPSRC), 10901049 (NSFC), 09C636 (HPED)|
1. Alon U: An introduction to Systems Biology: Design Principles of Biological
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