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Coexistence and specialization of pathogen strains on contact networks
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Eames, Ken T. D. and Keeling, Matthew James (2006) Coexistence and specialization of pathogen strains on contact networks. American Naturalist, Vol.168 (No.2). pp. 230-241. doi:10.1086/505760 ISSN 0003-0147.
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Official URL: http://dx.doi.org/10.1086/505760
Abstract
The coexistence of different pathogen strains has implications for pathogen variability and disease control and has been explained in a number of different ways. We use contact networks, which represent interactions between individuals through which infection could be transmitted, to investigate strain coexistence. For sexually transmitted diseases the structure of contact networks has received detailed study and has been shown to be a vital determinant of the epidemiological dynamics. By using analytical pairwise models and stochastic simulations, we demonstrate that network structure also has a profound influence on the interaction between pathogen strains. In particular, when the population is serially monogamous, fully cross-reactive strains can coexist, with different strains dominating in network regions with different characteristics. Furthermore, we observe specialization of different strains in different risk groups within the network, suggesting the existence of diverging evolutionary pressures.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QH Natural history > QH301 Biology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Science > Mathematics |
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Journal or Publication Title: | American Naturalist | ||||
Publisher: | University of Chicago Press | ||||
ISSN: | 0003-0147 | ||||
Official Date: | August 2006 | ||||
Dates: |
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Volume: | Vol.168 | ||||
Number: | No.2 | ||||
Number of Pages: | 12 | ||||
Page Range: | pp. 230-241 | ||||
DOI: | 10.1086/505760 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
Data sourced from Thomson Reuters' Web of Knowledge
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