Eames, Ken T. D. and Keeling, Matthew James. (2006) Coexistence and specialization of pathogen strains on contact networks. American Naturalist, Vol.168 (No.2). pp. 230-241. ISSN 0003-0147

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Abstract

The coexistence of different pathogen strains has implications for pathogen variability and disease control and has been explained in a number of different ways. We use contact networks, which represent interactions between individuals through which infection could be transmitted, to investigate strain coexistence. For sexually transmitted diseases the structure of contact networks has received detailed study and has been shown to be a vital determinant of the epidemiological dynamics. By using analytical pairwise models and stochastic simulations, we demonstrate that network structure also has a profound influence on the interaction between pathogen strains. In particular, when the population is serially monogamous, fully cross-reactive strains can coexist, with different strains dominating in network regions with different characteristics. Furthermore, we observe specialization of different strains in different risk groups within the network, suggesting the existence of diverging evolutionary pressures.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology
Divisions:	Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Science > Life Sciences (2010- ) Faculty of Science > Mathematics
Journal or Publication Title:	American Naturalist
Publisher:	University of Chicago Press
ISSN:	0003-0147
Date:	August 2006
Volume:	Vol.168
Number:	No.2
Number of Pages:	12
Page Range:	pp. 230-241
Identification Number:	10.1086/505760
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/33201

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