A naturally occurring epigenetic mutation in a gene encoding an SBP-box transcription factor inhibits tomato fruit ripening
Manning, Kenneth, Tör, Mahmut, Poole, Mervin, Hong, Yiguo , Thompson, Andrew J., King , Graham J., Giovannoni, James J. and Seymour, Graham B.. (2006) A naturally occurring epigenetic mutation in a gene encoding an SBP-box transcription factor inhibits tomato fruit ripening. Nature, Vol.38 (No.8). pp. 948-952. ISSN 0028-0836Full text not available from this repository.
Official URL: http://dx.doi.org/10.1038/ng1841
A major component in the regulatory network controlling fruit ripening is likely to be the gene at the tomato Colorless nonripening (Cnr) locus(1,2). The Cnr mutation results in colorless fruits with a substantial loss of cell-to-cell adhesion. The nature of the mutation and the identity of the Cnr gene were previously unknown. Using positional cloning and virus-induced gene silencing, here we demonstrate that an SBP-box (SQUAMOSA promoter binding protein-like) gene resides at the Cnr locus. Furthermore, the Cnr phenotype results from a spontaneous epigenetic change in the SBP-box promoter. The discovery that Cnr is an epimutation was unexpected, as very few spontaneous epimutations have been described in plants(3,4). This study demonstrates that an SBP-box gene is critical for normal ripening and highlights the likely importance of epialleles in plant development and the generation of natural variation.
|Item Type:||Journal Article|
|Subjects:||Q Science > QH Natural history > QH426 Genetics|
|Divisions:||Faculty of Science > Life Sciences (2010- )
Faculty of Science > Life Sciences (2010- ) > Warwick HRI (2004-2010)
|Journal or Publication Title:||Nature|
|Publisher:||Nature Publishing Group|
|Number of Pages:||5|
|Page Range:||pp. 948-952|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)|
Actions (login required)