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A naturally occurring epigenetic mutation in a gene encoding an SBP-box transcription factor inhibits tomato fruit ripening
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Manning, Kenneth, Tör, Mahmut, Poole, Mervin, Hong, Yiguo , Thompson, Andrew J., King , Graham J., Giovannoni, James J. and Seymour, Graham B.. (2006) A naturally occurring epigenetic mutation in a gene encoding an SBP-box transcription factor inhibits tomato fruit ripening. Nature, Vol.38 (No.8). pp. 948-952. ISSN 0028-0836
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Official URL: http://dx.doi.org/10.1038/ng1841
Abstract
A major component in the regulatory network controlling fruit ripening is likely to be the gene at the tomato Colorless nonripening (Cnr) locus(1,2). The Cnr mutation results in colorless fruits with a substantial loss of cell-to-cell adhesion. The nature of the mutation and the identity of the Cnr gene were previously unknown. Using positional cloning and virus-induced gene silencing, here we demonstrate that an SBP-box (SQUAMOSA promoter binding protein-like) gene resides at the Cnr locus. Furthermore, the Cnr phenotype results from a spontaneous epigenetic change in the SBP-box promoter. The discovery that Cnr is an epimutation was unexpected, as very few spontaneous epimutations have been described in plants(3,4). This study demonstrates that an SBP-box gene is critical for normal ripening and highlights the likely importance of epialleles in plant development and the generation of natural variation.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QH Natural history > QH426 Genetics |
| Divisions: | Faculty of Science > Life Sciences (2010- ) Faculty of Science > Life Sciences (2010- ) > Warwick HRI (2004-2010) |
| Journal or Publication Title: | Nature |
| Publisher: | Nature Publishing Group |
| ISSN: | 0028-0836 |
| Date: | August 2006 |
| Volume: | Vol.38 |
| Number: | No.8 |
| Number of Pages: | 5 |
| Page Range: | pp. 948-952 |
| Identification Number: | 10.1038/ng1841 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) |
| URI: | http://wrap.warwick.ac.uk/id/eprint/33250 |
Data sourced from Thomson Reuters' Web of Knowledge
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