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Engineering Escherichia coli to produce nonribosomal peptide antibiotics

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Challis, Gregory L. (2006) Engineering Escherichia coli to produce nonribosomal peptide antibiotics. Nature, 2 (8). pp. 398-400. ISSN 1552-4450

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Abstract

Genetic manipulation of biosynthetic pathways is a useful method for producing analogs of complex bioactive metabolites, but this technique can be challenging when performed in the natural producer of the target compounds. Reconstruction of biosynthetic gene clusters in E. coli could be the key to rapid heterologous production of natural products and genetic manipulation of their biosynthetic pathways.

Item Type: News Item
Subjects: Q Science > QD Chemistry
Journal or Publication Title: Nature
Publisher: NATURE PUBLISHING GROUP
ISSN: 1552-4450
Official Date: August 2006
Dates:
DateEvent
August 2006UNSPECIFIED
Volume: 2
Number: 8
Number of Pages: 4
Page Range: pp. 398-400
DOI: 10.1038/nchembio0806-398
Publication Status: Published

Data sourced from Thomson Reuters' Web of Knowledge

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