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Engineering Escherichia coli to produce nonribosomal peptide antibiotics
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Challis, Gregory L. (2006) Engineering Escherichia coli to produce nonribosomal peptide antibiotics. Nature, 2 (8). pp. 398-400. ISSN 1552-4450
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Abstract
Genetic manipulation of biosynthetic pathways is a useful method for producing analogs of complex bioactive metabolites, but this technique can be challenging when performed in the natural producer of the target compounds. Reconstruction of biosynthetic gene clusters in E. coli could be the key to rapid heterologous production of natural products and genetic manipulation of their biosynthetic pathways.
| Item Type: | News Item | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry | ||||
| Journal or Publication Title: | Nature | ||||
| Publisher: | NATURE PUBLISHING GROUP | ||||
| ISSN: | 1552-4450 | ||||
| Official Date: | August 2006 | ||||
| Dates: |
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| Volume: | 2 | ||||
| Number: | 8 | ||||
| Number of Pages: | 4 | ||||
| Page Range: | pp. 398-400 | ||||
| DOI: | 10.1038/nchembio0806-398 | ||||
| Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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