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Novel placental expression of 2,3-bisphosphoglycerate mutase

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Pritlove, D. C., Gu, Mei, Boyd, C. A. R., Randeva, Harpal S. and Vatish, Manu (2006) Novel placental expression of 2,3-bisphosphoglycerate mutase. Placenta, Vol.27 (No.8). pp. 924-927. doi:10.1016/j.placenta.2005.08.010 ISSN 0143-4004.

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Official URL: http://dx.doi.org/10.1016/j.placenta.2005.08.010

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Abstract

2,3-Bisphosphoglycerate mutase (2,3-BPGM), an erythroid-expressed enzyme, synthesises 2,3-bisphosphoglycerate (2,3-BPG), the allosteric modulator of haemoglobin. This ligand has a higher affinity for adult haemoglobin than for fetal haemoglobin and differential binding of it facilitates transfer of oxygen between adult and fetal blood by lowering the affinity of adult haemoglobin for oxygen. This paper reports the discovery that 2,3-BPGM is synthesised in non-erythroid cells of the human placenta. Western blot analysis of placental extracts revealed high levels of 2,3-BPGM in the human placenta. Immunohistochemical staining and in situ hybridisation experiments indicated that abundant 2,3-BPGM is present in the syncytiotrophoblast layer of the placental villi at the feto-maternal interface. A cytochemical staining technique showed that the placental 2,3-BPGM is active, indicating that 2,3-BPG is synthesised in the outermost cells of the placenta. These observations demonstrate an unexpected and abundant presence of an enzyme key to oxygen release from adult haemoglobin, at the interface between maternal and fetal circulations.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016)
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Placenta
Publisher: Elsevier Ltd.
ISSN: 0143-4004
Official Date: August 2006
Dates:
DateEvent
August 2006Published
Volume: Vol.27
Number: No.8
Number of Pages: 4
Page Range: pp. 924-927
DOI: 10.1016/j.placenta.2005.08.010
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

Data sourced from Thomson Reuters' Web of Knowledge

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