Vatish, Manu, Randeva, Harpal S. and Grammatopoulos, Dimitris K. (2006) Hormonal regulation of placental nitric oxide and pathogenesis of pre-eclampsia. Trends in Molecular Medicine, Vol.12 (No.5). pp. 223-233. ISSN 1471-4914

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Abstract

The placenta is central to foetal growth and development in mammalian pregnancy. Compromised placental function (as found in pre-eclampsia) often results in life-threatening situations for both mother and foetus. The nitric-oxide (NO) signalling cascade is important for placental function, in particular for the development of the vascular network and for maintaining vascular tone. This pathway seems to be regulated by multiple hormonal signals. Emerging evidence suggests that pathogenic mechanisms that are involved in abnormal placental function target specific molecules, such as hormone receptors, that regulate NO release and have subsequent dramatic consequences. Here, we discuss the current knowledge of NO function in the placenta, its hormonal regulation in normal pregnancy and in the pathophysiology of pre-eclampsia, its potential pathogenic mechanisms and possible use as a therapeutic target.

Item Type:	Journal Item
Subjects:	Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology R Medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI) Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Trends in Molecular Medicine
Publisher:	Elsevier Ltd. * Trends Journals
ISSN:	1471-4914
Date:	May 2006
Volume:	Vol.12
Number:	No.5
Number of Pages:	11
Page Range:	pp. 223-233
Identification Number:	10.1016/j.molmed.2006.03.003
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/33303

Data sourced from Thomson Reuters' Web of Knowledge

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