Hormonal regulation of placental nitric oxide and pathogenesis of pre-eclampsia
Vatish, Manu, Randeva, Harpal S. and Grammatopoulos, Dimitris K. (2006) Hormonal regulation of placental nitric oxide and pathogenesis of pre-eclampsia. Trends in Molecular Medicine, Vol.12 (No.5). pp. 223-233. ISSN 1471-4914Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.molmed.2006.03.003
The placenta is central to foetal growth and development in mammalian pregnancy. Compromised placental function (as found in pre-eclampsia) often results in life-threatening situations for both mother and foetus. The nitric-oxide (NO) signalling cascade is important for placental function, in particular for the development of the vascular network and for maintaining vascular tone. This pathway seems to be regulated by multiple hormonal signals. Emerging evidence suggests that pathogenic mechanisms that are involved in abnormal placental function target specific molecules, such as hormone receptors, that regulate NO release and have subsequent dramatic consequences. Here, we discuss the current knowledge of NO function in the placenta, its hormonal regulation in normal pregnancy and in the pathophysiology of pre-eclampsia, its potential pathogenic mechanisms and possible use as a therapeutic target.
|Item Type:||Journal Item|
|Subjects:||Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
|Divisions:||Faculty of Medicine > Warwick Medical School|
|Journal or Publication Title:||Trends in Molecular Medicine|
|Publisher:||Elsevier Ltd. * Trends Journals|
|Official Date:||May 2006|
|Number of Pages:||11|
|Page Range:||pp. 223-233|
|Access rights to Published version:||Restricted or Subscription Access|
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