Regulatory T cell adjustment of quorum growth thresholds and the control of local immune responses
Burroughs, Nigel John, Mendes de Olivira, Bruno Miguel Paz and Pinto, Alberto Adrego. (2006) Regulatory T cell adjustment of quorum growth thresholds and the control of local immune responses. Journal of Theoretical Biology, Volume 241 (Number 1). pp. 134-141. ISSN 0022-5193Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.jtbi.2005.11.010
The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion is examined by mathematical modelling. We demonstrate that cytokine dependent growth exhibits a quorum T cell population threshold that determines if immune responses develop on activation. Secretion inhibition manipulates the growth dynamics and effectively increases the quorum threshold, i.e. to develop immune responses a higher number of T cells need to be activated. Thus Treg induced secretion inhibition can provide a mechanism for tissue specific regulation of the balance between suppression (control) and immune responses, a balance that can be varied at the local tissue level through the regulation of the local active Treg population size. However, nonspecific inhibition is prone to escape of initially controlled autoimmune T cells through cross reactivity to pathogens and bystander proliferation on unrelated immune responses. (c) 2005 Elsevier Ltd. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Divisions:||Faculty of Science > Mathematics|
|Journal or Publication Title:||Journal of Theoretical Biology|
|Date:||7 July 2006|
|Number of Pages:||8|
|Page Range:||pp. 134-141|
|Access rights to Published version:||Restricted or Subscription Access|
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