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Multiple mechanisms involved in oxytocin-induced modulation of myometrial contractility
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UNSPECIFIED (2006) Multiple mechanisms involved in oxytocin-induced modulation of myometrial contractility. ACTA PHARMACOLOGICA SINICA, 27 (7). pp. 827-832. ISSN 1671-4083
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Official URL: http://dx.doi.org/10.1111/j.1745-7254.2006.00393.x
Abstract
Oxytocin is a small peptide hormone with multiple sites of action in human body. It regulates a large number of reproduction-related processes in all species. Particularly important is its ability to stimulate uterine contractility. This is achieved by multiple mechanisms involving sarcoplasmic reticulum Ca2+ release and sensitization of the contractile apparatus to Ca2+. In this paper, we review the data published by us and other groups on oxytocin-induced modulation of uterine contractility. We conclude that sensitization of contractile apparatus to Ca2+ is the most relevant physiological effect of oxytocin on human myometrium.
| Item Type: | Journal Item |
|---|---|
| Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
| Journal or Publication Title: | ACTA PHARMACOLOGICA SINICA |
| Publisher: | BLACKWELL PUBLISHING |
| ISSN: | 1671-4083 |
| Date: | July 2006 |
| Volume: | 27 |
| Number: | 7 |
| Number of Pages: | 6 |
| Page Range: | pp. 827-832 |
| Identification Number: | 10.1111/j.1745-7254.2006.00393.x |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/33388 |
Data sourced from Thomson Reuters' Web of Knowledge
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