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Multiple mechanisms involved in oxytocin-induced modulation of myometrial contractility

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Shmygol, Anatoly, Gullam, Joanna, Blanks, Andrew M. and Thornton, Steven (2006) Multiple mechanisms involved in oxytocin-induced modulation of myometrial contractility. Acta Pharmacoligica Sinica, Volume 27 (Number 7). pp. 827-832. doi:10.1111/j.1745-7254.2006.00393.x

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Official URL: http://dx.doi.org/10.1111/j.1745-7254.2006.00393.x

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Abstract

Oxytocin is a small peptide hormone with multiple sites of action in human body. It regulates a large number of reproduction-related processes in all species. Particularly important is its ability to stimulate uterine contractility. This is achieved by multiple mechanisms involving sarcoplasmic reticulum Ca2+ release and sensitization of the contractile apparatus to Ca2+. In this paper, we review the data published by us and other groups on oxytocin-induced modulation of uterine contractility. We conclude that sensitization of contractile apparatus to Ca2+ is the most relevant physiological effect of oxytocin on human myometrium.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Acta Pharmacoligica Sinica
Publisher: Blackwell Pubishing
ISSN: 1671-4083
Official Date: 29 May 2006
Dates:
DateEvent
19 May 2006Submitted
29 May 2006Accepted
Volume: Volume 27
Number: Number 7
Number of Pages: 6
Page Range: pp. 827-832
DOI: 10.1111/j.1745-7254.2006.00393.x
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

Data sourced from Thomson Reuters' Web of Knowledge

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