Multiple mechanisms involved in oxytocin-induced modulation of myometrial contractility
Shmygol, Anatoly , Gullam, Joanna, Blanks, Andrew M. and Thornton, Steven. (2006) Multiple mechanisms involved in oxytocin-induced modulation of myometrial contractility. Acta Pharmacoligica Sinica, Volume 27 (Number 7). pp. 827-832. ISSN 1671-4083Full text not available from this repository.
Official URL: http://dx.doi.org/10.1111/j.1745-7254.2006.00393.x
Oxytocin is a small peptide hormone with multiple sites of action in human body. It regulates a large number of reproduction-related processes in all species. Particularly important is its ability to stimulate uterine contractility. This is achieved by multiple mechanisms involving sarcoplasmic reticulum Ca2+ release and sensitization of the contractile apparatus to Ca2+. In this paper, we review the data published by us and other groups on oxytocin-induced modulation of uterine contractility. We conclude that sensitization of contractile apparatus to Ca2+ is the most relevant physiological effect of oxytocin on human myometrium.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
|Divisions:||Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI)
Faculty of Medicine > Warwick Medical School
|Journal or Publication Title:||Acta Pharmacoligica Sinica|
|Official Date:||29 May 2006|
|Number of Pages:||6|
|Page Range:||pp. 827-832|
|Access rights to Published version:||Restricted or Subscription Access|
Actions (login required)