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Multiple mechanisms involved in oxytocin-induced modulation of myometrial contractility
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Shmygol, Anatoly, Gullam, Joanna, Blanks, Andrew M. and Thornton, Steven (2006) Multiple mechanisms involved in oxytocin-induced modulation of myometrial contractility. Acta Pharmacoligica Sinica, Volume 27 (Number 7). pp. 827-832. doi:10.1111/j.1745-7254.2006.00393.x
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Official URL: http://dx.doi.org/10.1111/j.1745-7254.2006.00393.x
Abstract
Oxytocin is a small peptide hormone with multiple sites of action in human body. It regulates a large number of reproduction-related processes in all species. Particularly important is its ability to stimulate uterine contractility. This is achieved by multiple mechanisms involving sarcoplasmic reticulum Ca2+ release and sensitization of the contractile apparatus to Ca2+. In this paper, we review the data published by us and other groups on oxytocin-induced modulation of uterine contractility. We conclude that sensitization of contractile apparatus to Ca2+ is the most relevant physiological effect of oxytocin on human myometrium.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
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| Divisions: | Faculty of Medicine > Warwick Medical School | ||||||
| Journal or Publication Title: | Acta Pharmacoligica Sinica | ||||||
| Publisher: | Blackwell Pubishing | ||||||
| ISSN: | 1671-4083 | ||||||
| Official Date: | 29 May 2006 | ||||||
| Dates: |
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| Volume: | Volume 27 | ||||||
| Number: | Number 7 | ||||||
| Number of Pages: | 6 | ||||||
| Page Range: | pp. 827-832 | ||||||
| DOI: | 10.1111/j.1745-7254.2006.00393.x | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
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