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A DNA-binding copper(I) metallosupramolecular cylinder that acts as an artificial nuclease
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Childs, Laura J., Malina, J., Rolfsnes, B. E., Pascu, Mirela, Prieto, M. J., Broome, Mark John, Rodger, P. Mark, Sletten, Einar, Moreno, Virtudes, Rodger, Alison and Hannon, M. J. (2006) A DNA-binding copper(I) metallosupramolecular cylinder that acts as an artificial nuclease. Chemistry : a European journal, Vol.12 (No.18). pp. 4919-4927. doi:10.1002/chem.200600060 ISSN 0947-6539.
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Official URL: http://dx.doi.org/10.1002/chem.200600060
Abstract
The DNA binding of a dicationic pyridylimine-based dicopper(i) metallosupramolecular cylinder is reported together with its ability to act as an artificial nuclease. The cylinder binds strongly to DNA; more strongly than the spherical dication [Ru(phen)(3)](2+) (phen = 1,10-phenanthroline), but more weakly than the corresponding tetracationic cylinders. DNA coiling effects are not observed with this dication, in contrast to the situation with the previously reported tetracationic cylinder involving a similar ligand. Linear dichroism (LD) data suggests that the dicopper cylinder binds in a different orientation from that of the tetracationic iron cylinder. Furthermore, the dicopper cylinder shows DNA-cleavage activity in the presence of peroxide. Of particular note is that the cylinder displays a marked and unusual ability to cleave both DNA strands at the same site, probably reflecting its dinuclear nature and possibly its mode of binding to the DNA.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
| Journal or Publication Title: | Chemistry : a European journal | ||||
| Publisher: | Wiley ; V.C.H Verlag | ||||
| ISSN: | 0947-6539 | ||||
| Official Date: | 14 June 2006 | ||||
| Dates: |
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| Volume: | Vol.12 | ||||
| Number: | No.18 | ||||
| Number of Pages: | 9 | ||||
| Page Range: | pp. 4919-4927 | ||||
| DOI: | 10.1002/chem.200600060 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Leverhulme Trust (LT) , European Union (EU) | ||||
| Grant number: | Grant F/125/BC (LT), MARCY RTN HPRN-CT-2002-00175; Marie Curie fellowship HPMF-CT-2002-01856 (EU) |
Data sourced from Thomson Reuters' Web of Knowledge
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