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The role of rafts in the fibrillization and aggregation of prions
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Pinheiro, Teresa J. T. (2006) The role of rafts in the fibrillization and aggregation of prions. In: COST Meeting on Protein - Lipid Interactions, Dubrovnik, Croatia, Oct 06-08, 2005. Published in: Chemistry and Physics of Lipids, Vol.141 (No.1-2). pp. 66-71.
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Official URL: http://dx.doi.org/10.1016/j.chemphyslip.2006.02.02...
Abstract
A key molecular event in prion diseases is the conversion of the prion protein (PrP) from its normal cellular form (PrPC) to the disease-specific form (PrPSc). The transition from PrPC to PrPSc involves a major conformational change, resulting in amorphous aggregates and/or fibrillar amyloid deposits. Here several lines of evidence implicating membranes in the conversion of PrP are reviewed with a particular emphasis on the role of lipid rafts in the conformational transition of prion proteins. New correlations between in vitro biophysical studies and findings from cell biology work on the role of rafts in prion conversion are highlighted and a mechanism for the role of rafts in prion conversion is proposed. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
| Item Type: | Conference Item (Paper) |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Science > Life Sciences (2010- ) |
| Journal or Publication Title: | Chemistry and Physics of Lipids |
| Publisher: | Elsevier Ireland Ltd |
| ISSN: | 0009-3084 |
| Date: | June 2006 |
| Volume: | Vol.141 |
| Number: | No.1-2 |
| Number of Pages: | 6 |
| Page Range: | pp. 66-71 |
| Identification Number: | 10.1016/j.chemphyslip.2006.02.022 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | Royal Society (Great Britain) , Wellcome Trust (London, England), Medical Research Council (Great Britain) (MRC), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) |
| Grant number: | SHoWCAse 053914/Z/98/Z (WT), G9901445 (MRC), 88/BS516471 (BBSRC) |
| Conference Paper Type: | Paper |
| Title of Event: | COST Meeting on Protein - Lipid Interactions |
| Type of Event: | Conference |
| Location of Event: | Dubrovnik, Croatia |
| Date(s) of Event: | Oct 06-08, 2005 |
| URI: | http://wrap.warwick.ac.uk/id/eprint/33417 |
Data sourced from Thomson Reuters' Web of Knowledge
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