The Library
Kinesin-14 : the roots of reversal
Tools
Cross, R. A.. (2010) Kinesin-14 : the roots of reversal. BMC Biology, Vol.8 (No.107). ISSN 1741-7007
|
PDF
WRAP_Cross_Kinesin-14.pdf - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader Download (4Mb) |
Official URL: http://dx.doi.org/10.1186/1741-7007-8-107
Abstract
Kinesin-14 motor proteins step towards microtubule minus ends, in the opposite direction to other kinesins. Work on the still-enigmatic kinesin-14 mechanism published in BMC Structural Biology shows that the carboxyl terminus of the motor head undergoes a dock-undock cycle, like that of plus-end-directed kinesins.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QP Physiology |
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Cell Biology Faculty of Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Kinesin |
| Journal or Publication Title: | BMC Biology |
| Publisher: | BioMed Central Ltd. |
| ISSN: | 1741-7007 |
| Date: | 16 August 2010 |
| Volume: | Vol.8 |
| Number: | No.107 |
| Number of Pages: | 5 |
| Identification Number: | 10.1186/1741-7007-8-107 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access |
| Funder: | Marie Curie Cancer Care |
| References: | 1. Heuston E, Bronner CE, Kull FJ, Endow SA: A kinesin motor in a force-producing conformation. BMC Struct Biol 2010, 10:19. 2. Walker RA, Salmon ED, Endow SA: The Drosophila claret segregation protein is a minus-end directed motor molecule. Nature 1990, 347:780-782. 3. McDonald HB, Stewart RJ, Goldstein LS: The kinesin-like ncd protein of Drosophila is a minus end-directed microtubule motor. Cell 1990, 63:1159-1165. 4. Endow SA, Waligora KW: Determinants of kinesin motor polarity. Science 1998, 281:1200-1202. 5. Endow SA, Higuchi H: A mutant of the motor protein kinesin that moves in both directions on microtubules. Nature 2000, 406:913-916. 6. Yun M, Bronner CE, Park CG, Cha SS, Park HW, Endow SA: Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd. EMBO J 2003, 22:5382-5389. 7. Makino T, Morii H, Shimizu T, Arisaka F, Kato Y, Nagata K, Tanokura M: Reversible and irreversible coiled coils in the stalk domain of ncd motor protein. Biochemistry 2007, 46:9523-9532. 8. Endres NF, Yoshioka C, Milligan RA, Vale RD: A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd. Nature 2006, 439:875-878. 9. Khalil AS, Appleyard DC, Labno AK, Georges A, Karplus M, Belcher AM, Hwang W, Lang MJ: Kinesin’s cover-neck bundle folds forward to generate force. Proc Natl Acad Sci USA 2008, 105:19247-19252. 10. Vale RD, Milligan RA: The way things move: looking under the hood of molecular motor proteins. Science 2000, 288:88-95. 11. Grant BJ, McCammon JA, Caves LS, Cross RA: Multivariate analysis of conserved sequence-structure relationships in kinesins: coupling of the active site and a tubulin-binding sub-domain. J Mol Biol 2007, 368:1231-1248. 12. Hirose K, Akimaru E, Akiba T, Endow SA, Amos LA: Large conformational changes in a kinesin motor catalyzed by interaction with microtubules. Mol Cell 2006, 23:913-923. 13. Lang MJ, Hwang W: Motor proteins: kinesin drives with an underhead cam. Curr Biol 2010, 20:R408-R410. |
| URI: | http://wrap.warwick.ac.uk/id/eprint/3355 |
Data sourced from Thomson Reuters' Web of Knowledge
Actions (login required)
![]() |
View Item |
Tools
Tools

