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Kinesin-14 : the roots of reversal

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Cross, R. A.. (2010) Kinesin-14 : the roots of reversal. BMC Biology, Vol.8 (No.107). ISSN 1741-7007

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Official URL: http://dx.doi.org/10.1186/1741-7007-8-107

Abstract

Kinesin-14 motor proteins step towards microtubule minus ends, in the opposite direction to other kinesins. Work on the still-enigmatic kinesin-14 mechanism published in BMC Structural Biology shows that the carboxyl terminus of the motor head undergoes a dock-undock cycle, like that of plus-end-directed kinesins.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Cell Biology
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Kinesin
Journal or Publication Title: BMC Biology
Publisher: BioMed Central Ltd.
ISSN: 1741-7007
Date: 16 August 2010
Volume: Vol.8
Number: No.107
Number of Pages: 5
Identification Number: 10.1186/1741-7007-8-107
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Marie Curie Cancer Care
References: 1. Heuston E, Bronner CE, Kull FJ, Endow SA: A kinesin motor in a force-producing conformation. BMC Struct Biol 2010, 10:19. 2. Walker RA, Salmon ED, Endow SA: The Drosophila claret segregation protein is a minus-end directed motor molecule. Nature 1990, 347:780-782. 3. McDonald HB, Stewart RJ, Goldstein LS: The kinesin-like ncd protein of Drosophila is a minus end-directed microtubule motor. Cell 1990, 63:1159-1165. 4. Endow SA, Waligora KW: Determinants of kinesin motor polarity. Science 1998, 281:1200-1202. 5. Endow SA, Higuchi H: A mutant of the motor protein kinesin that moves in both directions on microtubules. Nature 2000, 406:913-916. 6. Yun M, Bronner CE, Park CG, Cha SS, Park HW, Endow SA: Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd. EMBO J 2003, 22:5382-5389. 7. Makino T, Morii H, Shimizu T, Arisaka F, Kato Y, Nagata K, Tanokura M: Reversible and irreversible coiled coils in the stalk domain of ncd motor protein. Biochemistry 2007, 46:9523-9532. 8. Endres NF, Yoshioka C, Milligan RA, Vale RD: A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd. Nature 2006, 439:875-878. 9. Khalil AS, Appleyard DC, Labno AK, Georges A, Karplus M, Belcher AM, Hwang W, Lang MJ: Kinesin’s cover-neck bundle folds forward to generate force. Proc Natl Acad Sci USA 2008, 105:19247-19252. 10. Vale RD, Milligan RA: The way things move: looking under the hood of molecular motor proteins. Science 2000, 288:88-95. 11. Grant BJ, McCammon JA, Caves LS, Cross RA: Multivariate analysis of conserved sequence-structure relationships in kinesins: coupling of the active site and a tubulin-binding sub-domain. J Mol Biol 2007, 368:1231-1248. 12. Hirose K, Akimaru E, Akiba T, Endow SA, Amos LA: Large conformational changes in a kinesin motor catalyzed by interaction with microtubules. Mol Cell 2006, 23:913-923. 13. Lang MJ, Hwang W: Motor proteins: kinesin drives with an underhead cam. Curr Biol 2010, 20:R408-R410.
URI: http://wrap.warwick.ac.uk/id/eprint/3355

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