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Structure-function properties of prolyl oligopeptidase family enzymes
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UNSPECIFIED (2006) Structure-function properties of prolyl oligopeptidase family enzymes. In: 1st Latin-American-Protein-Society Meeting, Angra dos Reis, BRAZIL, NOV 08-12, 2004. Published in: CELL BIOCHEMISTRY AND BIOPHYSICS, 44 (3). pp. 349-365. ISSN 1085-9195.
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Abstract
Prolyl oligopeptidase family enzymes regulate the activity of biologically active peptides and peptide hormones, and they are implicated in diseases, including amnesia, depression, diabetes, and trypanosomiasis. Distinctively, these enzymes hydrolyze only relatively short peptide substrates, while large structured peptides and proteins are not usually cleaved. Prolyl oligopeptidase has a C-terminal alpha/beta-hydrolase catalytic domain that is similar to lipases and esterases. An N-terminal beta-propeller domain regulates access to the buried active site, explaining the observed oligopeptidase activity. The catalytic and regulatory mechanisms have been investigated using a combination of X-ray crystallography, site-directed mutagenesis, and enzyme kinetic measurements. Crystal structures have now been determined for representative members of three of the four subfamilies and are facilitating a better understanding of the structure-function properties of these physiologically and pharmaceutically important enzymes.
Item Type: | Conference Item (UNSPECIFIED) | ||||
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Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
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Journal or Publication Title: | CELL BIOCHEMISTRY AND BIOPHYSICS | ||||
Publisher: | HUMANA PRESS INC | ||||
ISSN: | 1085-9195 | ||||
Official Date: | 2006 | ||||
Dates: |
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Volume: | 44 | ||||
Number: | 3 | ||||
Number of Pages: | 17 | ||||
Page Range: | pp. 349-365 | ||||
Publication Status: | Published | ||||
Title of Event: | 1st Latin-American-Protein-Society Meeting | ||||
Location of Event: | Angra dos Reis, BRAZIL | ||||
Date(s) of Event: | NOV 08-12, 2004 |
Data sourced from Thomson Reuters' Web of Knowledge
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