UNSPECIFIED (2006) The use of recently described ionisation techniques for the rapid analysis of some common drugs and samples of biological origin. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 20 (9). pp. 1447-1456. doi:10.1002/rcm.2470 ISSN 0951-4198.

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Abstract

Three ionisation techniques that require no sample preparation or extraction prior to mass analysis have been used for the rapid analysis of pharmaceutical tablets and ointments. These methods were M the novel direct analysis in real time (DART), (ii) desorption electrospray ionisation (DESI), and (iii) desorption atmospheric pressure chemical ionisation (DAPCI). The performance of the three techniques was investigated for a number of common drugs. Significant differences between these approaches were observed. For compounds of moderate to low polarity DAPCI produced more effective ionisation. Accurate DESI and DAPCI tandem mass spectra were obtained and these greatly enhance the selectivity and information content of the experiment. The detection from human skin of the active ingredients from ointments is reported together with the detection of ibuprofen metabolites in human urine. Copyright (c) 2006 John Wiley & Sons, Ltd.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry Q Science > QC Physics
Journal or Publication Title:	RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Publisher:	JOHN WILEY & SONS LTD
ISSN:	0951-4198
Official Date:	2006
Dates:	Date Event 2006 UNSPECIFIED
Volume:	20
Number:	9
Number of Pages:	10
Page Range:	pp. 1447-1456
DOI:	10.1002/rcm.2470
Publication Status:	Published

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