Islet endothelial cells and pancreatic beta-cell proliferation: Studies in vitro and during pregnancy in adult rats
UNSPECIFIED. (2006) Islet endothelial cells and pancreatic beta-cell proliferation: Studies in vitro and during pregnancy in adult rats. ENDOCRINOLOGY, 147 (5). pp. 2315-2324. ISSN 0013-7227Full text not available from this repository.
Official URL: http://dx.doi.org/10.1210/en.2005-0997
The growth of both tumors and nonneoplastic tissues may be influenced by signals from the vascular endothelium. In the present investigation we show that purified proliferating endothelial cells from pancreatic islets can stimulate beta-cell proliferation through secretion of hepatocyte growth factor (HGF). This secretion could be induced by soluble signals from the islets, such as vascular endothelial growth factor-A (VEGF-A) and insulin. During pregnancy, the pancreatic beta-cells display a highly reproducible physiological proliferation. We show that islet endothelial cell proliferation precedes beta-cell proliferation in pregnant animals. Vascular growth was closely associated with endocrine cell proliferation, and prominent expression of HGF was observed in islet endothelium on d 15 of pregnancy, i.e. coinciding with the peak of beta-cell proliferation. In summary, our results suggest the existence of an endothelial-endocrine axis within adult pancreatic islets, which is of importance for adult beta-cell proliferation.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine|
|Journal or Publication Title:||ENDOCRINOLOGY|
|Number of Pages:||10|
|Page Range:||pp. 2315-2324|
Actions (login required)