UNSPECIFIED. (2006) Islet endothelial cells and pancreatic beta-cell proliferation: Studies in vitro and during pregnancy in adult rats. ENDOCRINOLOGY, 147 (5). pp. 2315-2324. ISSN 0013-7227

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Abstract

The growth of both tumors and nonneoplastic tissues may be influenced by signals from the vascular endothelium. In the present investigation we show that purified proliferating endothelial cells from pancreatic islets can stimulate beta-cell proliferation through secretion of hepatocyte growth factor (HGF). This secretion could be induced by soluble signals from the islets, such as vascular endothelial growth factor-A (VEGF-A) and insulin. During pregnancy, the pancreatic beta-cells display a highly reproducible physiological proliferation. We show that islet endothelial cell proliferation precedes beta-cell proliferation in pregnant animals. Vascular growth was closely associated with endocrine cell proliferation, and prominent expression of HGF was observed in islet endothelium on d 15 of pregnancy, i.e. coinciding with the peak of beta-cell proliferation. In summary, our results suggest the existence of an endothelial-endocrine axis within adult pancreatic islets, which is of importance for adult beta-cell proliferation.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine
Journal or Publication Title:	ENDOCRINOLOGY
Publisher:	ENDOCRINE SOC
ISSN:	0013-7227
Date:	May 2006
Volume:	147
Number:	5
Number of Pages:	10
Page Range:	pp. 2315-2324
Identification Number:	10.1210/en.2005-0997
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/33681

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