Sens, Pierre and Turner, Matthew S. (2006) Budded membrane microdomains as tension regulators. Physical Review E (Statistical, Nonlinear, and Soft Matter Physics), Vol.73 (No.3 Part 1). Article: 031918. doi:10.1103/PhysRevE.73.031918 ISSN 1539-3755.

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Abstract

We propose a mechanism by which changes of the mechanical tension of a composite lipid membrane are buffered by the invagination of membrane domains. We show that domain invagination, driven by differences in chemical composition, is a first-order transition controlled by membrane tension. The invaginated domains play the role of a membrane reservoir, exchanging area with the main membrane, and impose an equilibrium tension entirely controlled by their mechanical properties. The dynamical response of the reservoir reflects the tension-dependent kinetics of the domain shape transition, so that the tension of such a composite membrane is inherently transient and dynamical. The implications of this phenomenon for the mechanical properties of the membranes of living cells, where invaginated membrane domains are known to exist, are discussed.

Item Type:	Journal Article
Subjects:	Q Science > QC Physics
Divisions:	Faculty of Science, Engineering and Medicine > Science > Physics
Journal or Publication Title:	Physical Review E (Statistical, Nonlinear, and Soft Matter Physics)
Publisher:	American Physical Society
ISSN:	1539-3755
Official Date:	March 2006
Dates:	Date Event March 2006 Published
Volume:	Vol.73
Number:	No.3 Part 1
Number of Pages:	4
Page Range:	Article: 031918
DOI:	10.1103/PhysRevE.73.031918
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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