Circulating vaspin is unrelated to insulin sensitivity in a cohort of nondiabetic humans
Loeffelholz, Christian von, Möhlig, Matthias, Arafat, Ayman, M., Isken, Frank, Spranger, Joachim, Mai, Knut, Randeva, Harpal S., Pfeiffer, Andreas F. H. and Weickert, Martin O.. (2010) Circulating vaspin is unrelated to insulin sensitivity in a cohort of nondiabetic humans. European Journal of Endocrinology, Vol.162 (No.3). pp. 507-513. ISSN 0804-4643
WRAP_Weickert_-j-endocrinol_2010.pdf - Draft Version - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Official URL: http://dx.doi.org/10.1530/EJE-09-0737
Objective: To study the association of vaspin with glucose metabolism.
Design: Cross-sectional and intervention study.
Subjects and methods: The association of serum vaspin with metabolic and anthropometric characteristics was investigated in 108 volunteers. Euglycemic–hyperinsulinemic clamps (EHC) were performed in 83 of the participants. Changes of circulating vaspin levels were additionally studied in a crossover study using 300 min EHC with lipid versus saline infusion (n=10).
Results: Neither glucose tolerance status nor insulin sensitivity, both as measured using EHCs and using homeostasis model assessment for insulin resistance (HOMA-IR), was significantly associated with serum vaspin in the cross-sectional study. Furthermore, there was no effect of short-term lipid-induced insulin resistance due to a 300 min intravenous lipid challenge on circulating vaspin. However, circulating vaspin levels were significantly elevated in women using oral contraceptives (OC), both compared to women without OC intake (1.17±0.26 vs 0.52±0.09 ng/ml, P=0.02) and males (1.17±0.26 vs 0.29±0.04 ng/ml, P=0.01). After exclusion of OC using females and stratification according to body mass index (BMI), a significant sexual dimorphism in subjects with a BMI <25 kg/m2 was observed (males 0.21±0.04 ng/ml versus females 0.70±0.16 ng/ml, P=0.009).
Conclusion: Our results support the existence of a sexual dimorphism regarding circulating vaspin. The lack of an association of serum vaspin with HOMA-IR and M value indicates, however, no major role for vaspin concerning insulin sensitivity in nondiabetic humans.
|Item Type:||Journal Article|
|Alternative Title:||Serum vaspin and insulin sensitivity|
|Subjects:||Q Science > QP Physiology|
|Divisions:||Faculty of Medicine > Warwick Medical School > Translational & Systems Medicine > Metabolic and Vascular Health
Faculty of Medicine > Warwick Medical School
|Library of Congress Subject Headings (LCSH):||Blood sugar, Insulin, Serine proteinases -- Inhibitors, Adipose tissues|
|Journal or Publication Title:||European Journal of Endocrinology|
|Official Date:||1 March 2010|
|Page Range:||pp. 507-513|
|Access rights to Published version:||Open Access|
|Funder:||Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke [German Institute of Human Nutrition Potsdam-Rehbrücke]|
1. Rabe K, Lehrke M, Parhofer KG & Broedl UC: Adipokines and insulin resistance. Molecular Medicine 2008 14 741-751.
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