UNSPECIFIED (2006) Deforming biological membranes: How the cytoskeleton affects a polymerizing fiber. JOURNAL OF CHEMICAL PHYSICS, 124 (2). -. doi:10.1063/1.2148960 ISSN 0021-9606.

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Abstract

We give a theoretical treatment of the force exerted by a fluctuating membrane on a polymer rod tip, taking into account the effects of an underlying biological cytoskeleton by way of a simple harmonic dependence on displacement. We also consider theoretically and experimentally the dynamics of a growing fiber tip under the influence of such a fluctuation-induced membrane force, including the effects of an underlying cytoskeletal network. We compare our model with new experimental data for the growth of hemoglobin fibers within red blood cells, revealing a good agreement. We are also able to estimate the force and membrane/cytoskeletal displacement required to stall growth of, or buckle, a growing fiber. We discuss the significance of our results in a biological context, including how the properties of the membrane and cytoskeleton relate to the thermodynamics of rod polymerization. (c) 2006 American Institute of Physics.

Item Type:	Journal Article
Subjects:	Q Science > QC Physics
Journal or Publication Title:	JOURNAL OF CHEMICAL PHYSICS
Publisher:	AMER INST PHYSICS
ISSN:	0021-9606
Official Date:	14 January 2006
Dates:	Date Event 14 January 2006 UNSPECIFIED
Volume:	124
Number:	2
Number of Pages:	8
Page Range:	-
DOI:	10.1063/1.2148960
Publication Status:	Published

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