Isken, Frank, Weickert, Martin O., Tschöp, M. H., Nogueiras, R., Möhlig, Matthias, Abdelrahman, A., Klaus, Susanne, Thorens, B. and Pfeiffer, Andreas F. H. (2009) Metabolic effects of diets differing in glycaemic index depend on age and endogenous GIP. Diabetologia, Vol.52 (No.10). pp. 2159-2168. ISSN 0012-186X

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Abstract

Aims/hypothesis High- vs low-glycaemic index (GI) diets unfavourably affect body fat mass and metabolic markers in rodents. Different effects of these diets could be age-dependent, as well as mediated, in part, by carbohydrate-induced stimulation of glucose-dependent insulinotrophic polypeptide (GIP) signalling. Methods Young-adult (16 weeks) and aged (44 weeks) male wild-type (C57BL/6J) and GIP-receptor knockout (Gipr −/− ) mice were exposed to otherwise identical high-carbohydrate diets differing only in GI (20–26 weeks of intervention, n = 8–10 per group). Diet-induced changes in body fat distribution, liver fat, locomotor activity, markers of insulin sensitivity and substrate oxidation were investigated, as well as changes in the gene expression of anorexigenic and orexigenic hypothalamic factors related to food intake. Results Body weight significantly increased in young-adult high- vs low-GI fed mice (two-way ANOVA, p < 0.001), regardless of the Gipr genotype. The high-GI diet in young-adult mice also led to significantly increased fat mass and changes in metabolic markers that indicate reduced insulin sensitivity. Even though body fat mass also slightly increased in high- vs low-GI fed aged wild-type mice (p < 0.05), there were no significant changes in body weight and estimated insulin sensitivity in these animals. However, aged Gipr −/− vs wild-type mice on high-GI diet showed significantly lower cumulative net energy intake, increased locomotor activity and improved markers of insulin sensitivity. Conclusions/interpretation The metabolic benefits of a low-GI diet appear to be more pronounced in younger animals, regardless of the Gipr genotype. Inactivation of GIP signalling in aged animals on a high-GI diet, however, could be beneficial.

Item Type:	Submitted Journal Article
Subjects:	Q Science > QL Zoology
Divisions:	Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Glycemic index, Mice -- Health, Mice -- Food, Insulin resistance, Non-insulin-dependent diabetes -- Age factors
Journal or Publication Title:	Diabetologia
Publisher:	Springer
ISSN:	0012-186X
Date:	October 2009
Volume:	Vol.52
Number:	No.10
Page Range:	pp. 2159-2168
Identification Number:	10.1007/s00125-009-1466-9
Status:	Peer Reviewed
Access rights to Published version:	Restricted or Subscription Access
Funder:	Deutsche Forschungsgemeinschaft (DFG), Germany. Bundesministerium für Bildung und Forschung (BMBF)
Grant number:	PF 164/14-1 (DFG), 0313826A (BMBF)
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URI:	http://wrap.warwick.ac.uk/id/eprint/3403

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