Metabolic effects of diets differing in glycaemic index depend on age and endogenous GIP
Isken, Frank, Weickert, Martin O., Tschöp, M. H., Nogueiras, R., Möhlig, Matthias, Abdelrahman, A., Klaus, Susanne, Thorens, B. and Pfeiffer, Andreas F. H. (2009) Metabolic effects of diets differing in glycaemic index depend on age and endogenous GIP. Diabetologia, Vol.52 (No.10). pp. 2159-2168. ISSN 0012-186X
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Official URL: http://dx.doi.org/10.1007/s00125-009-1466-9
High- vs low-glycaemic index (GI) diets unfavourably affect body fat mass and metabolic markers in rodents. Different effects of these diets could be age-dependent, as well as mediated, in part, by carbohydrate-induced stimulation of glucose-dependent insulinotrophic polypeptide (GIP) signalling.
Young-adult (16 weeks) and aged (44 weeks) male wild-type (C57BL/6J) and GIP-receptor knockout (Gipr −/− ) mice were exposed to otherwise identical high-carbohydrate diets differing only in GI (20–26 weeks of intervention, n = 8–10 per group). Diet-induced changes in body fat distribution, liver fat, locomotor activity, markers of insulin sensitivity and substrate oxidation were investigated, as well as changes in the gene expression of anorexigenic and orexigenic hypothalamic factors related to food intake.
Body weight significantly increased in young-adult high- vs low-GI fed mice (two-way ANOVA, p < 0.001), regardless of the Gipr genotype. The high-GI diet in young-adult mice also led to significantly increased fat mass and changes in metabolic markers that indicate reduced insulin sensitivity. Even though body fat mass also slightly increased in high- vs low-GI fed aged wild-type mice (p < 0.05), there were no significant changes in body weight and estimated insulin sensitivity in these animals. However, aged Gipr −/− vs wild-type mice on high-GI diet showed significantly lower cumulative net energy intake, increased locomotor activity and improved markers of insulin sensitivity.
The metabolic benefits of a low-GI diet appear to be more pronounced in younger animals, regardless of the Gipr genotype. Inactivation of GIP signalling in aged animals on a high-GI diet, however, could be beneficial.
|Item Type:||Submitted Journal Article|
|Subjects:||Q Science > QL Zoology|
|Divisions:||Faculty of Medicine > Warwick Medical School|
|Library of Congress Subject Headings (LCSH):||Glycemic index, Mice -- Health, Mice -- Food, Insulin resistance, Non-insulin-dependent diabetes -- Age factors|
|Journal or Publication Title:||Diabetologia|
|Official Date:||October 2009|
|Page Range:||pp. 2159-2168|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Deutsche Forschungsgemeinschaft (DFG), Germany. Bundesministerium für Bildung und Forschung (BMBF)|
|Grant number:||PF 164/14-1 (DFG), 0313826A (BMBF)|
 Pawlak DB, Kushner JA, Ludwig DS (2004) Effects of dietary glycaemic index on adiposity, glucose homoeostasis, and plasma lipids in animals. Lancet 364: 778-785
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